Erythroblast

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erythroblast

[ə′rith·rə‚blast]
(histology)
A nucleated cell occurring in bone marrow as the earliest recognizable cell of the erythrocytic series.

Erythroblast

 

intermediate form of development of a red blood cell, or erythrocyte. In mammals and in man, erythroblasts have nuclei and reproduce themselves, unlike mature erythrocytes, which lack nuclei and are unable to reproduce.

In the lower vertebrates (reptiles, amphibians, and fishes), hematopoiesis takes place in the liver, the kidneys, and partly the blood vessels, where erythroblasts may be found together with mature erythrocytes. During the embryonic development of the higher, or warm-blooded, vertebrates (birds and mammals) and man, erythroblasts are formed in the vessels of the yolk sac and transformed into primary erythrocytes, which soon die. In man, they concentrate after birth in the bone marrow, where they develop from hemocytoblasts; it is only in pathological cases that erythroblasts are found in peripheral blood. The number of erythroblasts and their rate of reproduction increase in anemia. After the erythrocyte level in the blood is restored to normal, erythroblast activity in the bone marrow declines.

References in periodicals archive ?
We studied the methylation profiles of erythroblasts and other blood cells (neutrophils, B-lymphocytes, and T-lymphocytes) and tissues (liver, lung, colon, small intestines, pancreas, adrenal gland, esophagus, heart, brain, and placenta) from the BLUEPRINT Project and the Roadmap Epigenomics Project and methylomes generated by our group (18-20, 23).
ERFE is a newly identified hormone, produced by erythroblasts, following EPO stimulus, which blocks hepcidin production [6, 33, 34].
High expression of cell surface markers for erythroblasts (glycophorin A), megakaryocytes (CD41), and granulocytes (MPO) was observed.
An EryD region was added according to the results by Chen et al., who localized a gate where orthochromic erythroblasts with nuclear-cytoplasmic dyssynchrony fall [19].
CALR expression in erythroblasts and granulocytes is also downregulated from [CD34.sup.+] cells, suggesting CALR's crucial role in platelet functions.
Radioprotective effects of the thiols GSH and WR-2721 against X-ray-induction of micronuclei in erythroblasts. Mutat Res.
(That is, the assumption that fetal cells are available only by [uterine] invasive methods was not strictly correct.) These fetal cells include erythroblasts, trophoblasts, granulocytes, and lymphocytes, all of which are nucleated and could theoretically be amenable to cytogenetic analysis.
In adults, HLA-G is found in the cornea, thymus, pancreas, endothelial cell precursors, and erythroblasts [78].
The cord blood unit (CBU) contained 45.8 mL blood, cryopreserved by 6.0% DMSO (w/v), with a total nucleated cell count (TNC) of 2.53 x 10e8 mononuclear cells without erythroblasts, but including 0.72 x 10e6 CD34+ (15.8/mL), and 0.23 x 10e6 colony forming cells (CFC) (vitality 84.4%, hemoglobin 91.8 [mg/mL]).
The biliary canaliculi had less microvillus in the experimental group and the erythroblasts were atypically condensed, so that the heterochromatin appeared to be more abundant (Figs.
Together with muscle cells these differentiated cells are among the most radioresistant in the human body, while the most sensitive cells are spermatogonia and erythroblasts, epidermal stem cells and gastrointestinal stem cells.