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A hormone, thought to be produced by the kidneys, that regulates erythropoiesis, at least in higher vertebrates.



a hormone that stimulates the formation of erythrocytes in bone marrow. Characterized as a glycoprotein, erythropoietin has a carbohydrate content of 35 percent. It has a molecular weight of 30,000–40,000 and possesses antigenic properties. Erythropoietin is inactivated by neuraminidase, trypsin, chymotrypsin, and papain.

Erythropoietin was discovered by the French researchers F. Corneau and C. de Flandre in 1906 in rabbit serum that they tested after drawing blood. The hormone is found in low concentrations under normal physiological conditions, but the levels increase when the subject is in a state of hypoxia as a result of the loss of blood, a decrease in the oxygen content of the air, or various forms of anemia. Most scientists believe that erythropoietin is formed in the kidneys. When the hormone acts on stem cells in bone marrow, it causes their differentiation into cells of the erythroid series.


Fedorov, N. A., and M. G. Kakhetelidze. Eritropoetin. Moscow, 1973.
Normal’noe krovetvorenie i ego reguliatsiia. Moscow, 1976.
Gordon, A. S. Regulation of Hematopoiesis, vol. 1. New York [1970].


References in periodicals archive ?
Hinault's compatriot Laurent Jalabert was this week accused of taking the banned blood booster erythropoetin (EPO) on the scandal-hit 1998 Tour.
However, in a meta-analysis with more than 13,000 cancer patients erythropoetin treatment was found to increase mortality by 17% and should therefore be used extremely carefully (Bohlius et al.
In of 2007, the RPN scope of practice was further increased to include administration of Erythropoetin IV push during hemodialysis.
Many comparative studies are blinded to ensure that bias does not compromise the results * Erythropoetin (EPO) is a medication that is often given to treat ribavirin-related anemia and help patients maintain a higher ribavirin dose.
World cross-country champion Radcliffe was angry that Yegorova was allowed to compete on a technicality after testing positive for the banned hormone erythropoetin (EPO) at a meeting in Paris last month.
EPO, short for erythropoetin, was created by Amgen in the early 1980s and is now one the top selling drugs in the world.
Similar amounts of supportive care medications, including antibiotics, antiemetics, granulocyte stimulating factors and erythropoetin, were administered to the two groups.
For Thousand Oaks-based Amgen, the issue is protecting its crown jewel: erythropoetin, or EPO, also known by its trade name Epogen.
Erythropoiesis Stimulating Agents (ESA), injectable supplements of recombinant human erythropoetin or analogs, were first made available in China in the early 1990's at high Western prices.
Shantha's development-stage product portfolio includes biotechnology products such as erythropoetin, G-CSF, insulin and tPA, as well as monoclonal antibodies directed at various cancer types, vaccines and diagnostic kits.
to terminate the right of its Ortho Biotech subsidiary to sell erythropoetin (EPO) in the United States.