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A hormone, thought to be produced by the kidneys, that regulates erythropoiesis, at least in higher vertebrates.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a hormone that stimulates the formation of erythrocytes in bone marrow. Characterized as a glycoprotein, erythropoietin has a carbohydrate content of 35 percent. It has a molecular weight of 30,000–40,000 and possesses antigenic properties. Erythropoietin is inactivated by neuraminidase, trypsin, chymotrypsin, and papain.

Erythropoietin was discovered by the French researchers F. Corneau and C. de Flandre in 1906 in rabbit serum that they tested after drawing blood. The hormone is found in low concentrations under normal physiological conditions, but the levels increase when the subject is in a state of hypoxia as a result of the loss of blood, a decrease in the oxygen content of the air, or various forms of anemia. Most scientists believe that erythropoietin is formed in the kidneys. When the hormone acts on stem cells in bone marrow, it causes their differentiation into cells of the erythroid series.


Fedorov, N. A., and M. G. Kakhetelidze. Eritropoetin. Moscow, 1973.
Normal’noe krovetvorenie i ego reguliatsiia. Moscow, 1976.
Gordon, A. S. Regulation of Hematopoiesis, vol. 1. New York [1970].


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Reliance Life Sciences (RLS) is also currently conducting clinical studies for erythropoetin along with its G-CSF in Europe.
Now, Cuba is aiming to sell abroad the genetically engineered protein erythropoetin, or EPO, which is by far the best-selling biotechnology drug.
Several years ago, a team was thrown out of the Tour de France after it was discovered they were taking erythropoetin (EPO)--a hormone that increases red blood cells, thereby increasing oxygen supply and improving endurance.
(Since 1998, dialysis facilities have been required to report each patient's most recent URR [reported as a range rather than the actual URR value] when submitting a claim to Medicare for that patient's hemodialysis treatment and since 1989, they have been required to report each patient's last monthly hematocrit value when submitting a claim for erythropoetin.) All of the calculated measures were produced by the UMKECC for CMS.
Every process that you can think of--from insulin used for diabetes to erythropoetin, a protein being used to increase red blood cells--happens at that level.
A new medication called epogen takes the place of the body's own erythropoetin. Epogen becomes director of red-blood-cell production and tells the bone marrow to make more red blood cells.
Beta-endorphin, enkephalins, melanocyte stimulating hormone, thyroxin, thyro-tropin, vasopressin, aldosterone, renin, erythropoetin, growth hormone, insulin, glucagon, prolactin, parathyroid hormone, calcitonin, and gastrin have all been shown to increase during stress, though the exact significance of these elevations has not been worked out in all cases (Jemmott & Locke, 1984; Borysenko & Borysenko, 1982).
Yegorova was originally suspended after she tested positive for the banned hormone erythropoetin (EPO) following a meet in Paris on July 6.
The correlation between sTfR and bone marrow erythropoetic activity allows the use of sTfR for monitoring erythropoetin therapy, with sTfR increasing 4 weeks before the first increase of hemoglobin (7).
The Italian daily La Republica carried reports claiming the athletes took the banned oxygen boosting hormone erythropoetin (EPO) in 1992 and 1993.
Cholesterol testing and diet therapy only $452 Antihypertensive therapy to prevent stroke (age 45-64) 1932 Coronary artery bypass grafting 4295 Kidney transplant 9679 Adjuvant 5-FU/levamisole for Duke's C colonic cancer (Smith et al, 1993) 11725(#) Hospital hemodialysis 45148 Erythropoetin treatment for anemia in dialysis patients 111751
One additional promissing development is a genetically engineered drug called erythropoetin (EPO) that regenerates red blood cells.