Erythropoietin

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Related to Erythropoietins: Hemopoietin, erythropoietin stimulating factor

erythropoietin

[ə‚rith·rə′pȯi·ət·ən]
(biochemistry)
A hormone, thought to be produced by the kidneys, that regulates erythropoiesis, at least in higher vertebrates.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Erythropoietin

 

a hormone that stimulates the formation of erythrocytes in bone marrow. Characterized as a glycoprotein, erythropoietin has a carbohydrate content of 35 percent. It has a molecular weight of 30,000–40,000 and possesses antigenic properties. Erythropoietin is inactivated by neuraminidase, trypsin, chymotrypsin, and papain.

Erythropoietin was discovered by the French researchers F. Corneau and C. de Flandre in 1906 in rabbit serum that they tested after drawing blood. The hormone is found in low concentrations under normal physiological conditions, but the levels increase when the subject is in a state of hypoxia as a result of the loss of blood, a decrease in the oxygen content of the air, or various forms of anemia. Most scientists believe that erythropoietin is formed in the kidneys. When the hormone acts on stem cells in bone marrow, it causes their differentiation into cells of the erythroid series.

REFERENCES

Fedorov, N. A., and M. G. Kakhetelidze. Eritropoetin. Moscow, 1973.
Normal’noe krovetvorenie i ego reguliatsiia. Moscow, 1976.
Gordon, A. S. Regulation of Hematopoiesis, vol. 1. New York [1970].

N. A. FEDOROV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Development of radioimmunoassays for human erythropoietin using recombinant erythropoietin as tracer and immunogen.
Pure red-cell aplasia and recombinant erythropoietin. New England Journal of Medicine, 346(20), 1584-1586.
Antibodies against recombinant human erythropoietin in a patient with erythropoietin-resistant anemia.
Pure red cell aplasia: studies on an IgG serum inhibitor neutralizing erythropoietin. British Journal of Haematology, 30(4), 411-417.
Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 1985;313:806-810.
Structural characterization of natural human urinary and recombinant DNA-derived erythropoietin. J Biol Chem 1987;262:17156-17163.
Erythropoietin and Its Relationship With the Erythrpoietin Receptor
Erythropoietin is the key hormone responsible for governing RBC development.
The erythropoietin gene is located on chromosome 7 in humans (Jelkmann, 1992).
Clinical trials of erythropoietin in acute kidney injury
RB and AN are investigators of a National Health and Medical Research Council/Victorian Neurotrauma Initiative funded clinical trial of Erythropoietin in Traumatic Brain Injury (NCT00987454).
Purification of human erythropoietin. J Biol Chem 1977; 252:5558-5564.