Esophagitis


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esophagitis

[ə‚säf·ə′jīd·əs]
(medicine)
Inflammation of the esophagus.

Esophagitis

 

inflammation of the mucosa of the esophagus. Esophagitis may be an independent disease or, more often, a symptom of another disease of the esophagus, stomach, or other organ. The inflammation is frequently caused by chemical, mechanical, or thermal irritation of the esophagus; for example, it may be caused by eating very hot and spicy food.

Catarrhal, phlegmonous, necrotic, and other forms of esophagitis are distinguished based on the severity of the inflammatory changes. In severe cases the inflammatory process may extend to the muscular layer of the esophagus, and sometimes, to the surrounding mediastinal tissue, giving rise to mediastinitis. One form of the disease, peptic esophagitis, is caused mostly by a reflux of the acidic contents of the stomach into the esophageal lumen in cases of hiatus hernia. Peptic esophagitis is sometimes associated with the development of an ulcer in the esophageal wall.

The course of the disease may be acute or chronic. Chronic esophagitis is frequently caused by alcohol abuse or smoking. The symptoms include a burning sensation, retrosternal pain on swallowing, excessive salivation, and regurgitation of food. Esophagoscopy is sometimes used to diagnose the disease. Treatment is by diet (eliminating coarse, hot, and acidic foods), pain relievers, astringent and antispasmodic drugs, and, in some forms, antibiotics and surgery.

REFERENCE

Vasilenko, V. Kh., A. L. Grebnev, and M. M. Sal’man. Bolezni pishchevoda. Moscow, 1971.

I. V. IAREMA

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Esophageal eosinophil counts and dysphagia improved in patients with comorbid eosinophilic esophagitis.
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The diagnosis of eosinophilic esophagitis was confirmed by histologic examination (Figures 6a and 6b).
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Eosinophilic esophagitis is predominantly seen in male patients between 30 and 40 years old.
Eosinophilic Esophagitis is a chronic, allergic inflammatory disease characterised by eosinophilic infiltration of the esophagus, which can lead to inflammation and ultimately strictures and narrowing of the esophagus, putting patients at risk of food impaction.
Studies have shown that over half of patients in Western countries that have reflux esophagitis also have hiatal hernias.
Mansoor, who is now a Gastroenterology Fellow in the Digestive Health Institute at University Hospitals Cleveland Medical Center/Case Western Reserve University, said: "What was really interesting was that we found an overall prevalence of celiac disease in eosinophilic esophagitis patients of two percent, which is a rather high prevalence given that in the general population the prevalence of celiac disease ranges from 0.25 to one percent at best.
The mean esophagus dose for each individual lung patients were correlated with esophagitis grade 1 and 2 using binary logistic regression and probit statistical analysis.
Chehade's project entitled "Impact of Proton Pump Inhibitors on the Esophageal Transcriptome in Eosinophilic Esophagitis Subtypes" will receive funding of $70,000 per year for two years (a total of $140,000).
In this retrospective study all pediatric patients seen at the Eosinophilic Esophagitis Clinic, Advocate Children's Hospital, Park Ridge, IL, over 2 and 1/2 years (1/2010-6/2012) with eosinophilic esophagitis were included in the study.
Reflux esophagitis is a condition which causes erosion of the mucosal lining of the esophagus due to the regurgitation of stomach acid and other causes, as well as frequent and persistent symptoms such as heartburn, discomfort in the throat and belching, with repeated recurrence and recrudescence.