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Though this assay has not been used (to our knowledge) for characterizations of crustacean nonspecific esterases, it has been used for larval studies with teleost fish (Bishop and Watts, 1997; Gjellesvik et al.
This report supports the earlier study of Loizzi and Peterson (1971), who found two different Tween-60 esterases in Procambarus clarkii; one had an optimum at pH of 7.
Indeed, the greater toxicity of chlorpyrifos in juvenile animals cannot be explained solely by developmental differences in activities directed toward cholinesterase or neurotoxic esterase, nor do age-related increments in chlorpyrifos metabolism account for differential toxicity (12); immature animals actually recover more rapidly from cholinesterase inhibition, so measurements of cholinesterase activity other than in the immediate exposure period can give a misleading assessment of adverse effects (7,13-15).
Previous work with PC12 cells suggested that horse serum, although heat-inactivated, nevertheless might maintain sufficient A esterase and carboxylesterase activity to hydrolyze chlorpyrifos oxon and thus provide protection from its adverse effects (11).
HYG-102 is the first estrogenic drug candidate engineered to be rapidly deactivated to a non-estrogenic metabolite by hydrolytic esterase enzymes and represents a new generation of topically effective estrogens with minimal systemic liability.
Under the grant, the company will also perform studies documenting the ability of CLEC lipases and esterases to remain stable and active in the harsh environments encountered in industrial applications that typically destroy conventional biocatalysts.
Our research focuses on customizing the enzymes we discovered in our Phase I research, as well as identifying additional esterase and lipase genes which can be developed and optimized further for multiple uses.
We measured the response of 3 detoxifying enzyme systems: general esterase (EST), glutathione S-transferase (GST), and cytochrome P450 monooxygenase (P450).
Dyadic") (OTCQX: DYAI), a global biotechnology company focused on the discovery, development, manufacture and sale of enzymes and other proteins for the bioenergy, bio-based chemicals, biopharmaceutical, food and feed industries, announced today details regarding its new project , " OPTIBIOCAT - Optimized esterase biocatalysts for cost-effective industrial production", an EU-funded project aimed at developing biocatalysts for the cosmetic industry.
The activities of esterases and polysaccharide hydrolases showed different trends and different peaks during the 10-day experimental period (Figures not shown).
Because in the calcein-AM assay the possible ability of test compounds to inhibit esterases might interfere with the measurement of P-gp activity, test compounds were also screened for esterase inhibition.
NIMES, France -- Within the frame of its collaboration with Degussa, Proteus has discovered and developed a highly thermostable esterase biocatalyst from a Pyrococcus sp.