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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
US Food and Drug Administration final approval for the generic Estrace Cream was awarded to the company's manufacturing and development partner, Perrigo Company plc (NYSE:PRGO)(TASE:PRGO) in late January.
General Medicine revenues were $1.3 billion, down 8%, impacted by lower revenues from NAMENDA XR and ESTRACE due to generic competition, offset by growth from-VRAYLAR, LINZESS, Lo LOESTRIN and anti-infectives including AVYCAZ.
M2 EQUITYBITES-January 25, 2018-Perrigo passes US FDA's final approval for generic Estrace Cream
M2 PHARMA-January 25, 2018-Perrigo passes US FDA's final approval for generic Estrace Cream
There are two main types of bioidentical hormones: those that are FDA-approved and commercially available with a prescription, such as Estrace, Climara, Vivelle, EstroGel, Divigel and Estrasorb, and those that are produced on an individual basis for women, in compounding pharmacies.
FDA-approved estradiol-containing products to treat hot flashes include Alora, Climera, Divigel, Estrace, Estraderm, Estrogel, Evamist, and Vivelle.
However, bio-identical estradiol in pill form (brand names: Estrace, Tri-Est, Bi-Est) has the negative effect of increasing blood clots because it is not natural for estrogen to enter the bloodstream through the stomach.
$7.72 * for 3 days topical estradiol 0.5-2 g/day $1.14 (1 g) ** (Estrace) nitrofurantoin 100 mg b.i.d.
We measured serum estrone because some women, when questioned about their use of exogenous estrogens, equate ERT with occasional use of preparations such as Estrace or Premarin or using transdermal estrogen patches and vaginal creams, which do not have the same effect as oral estrogens in raising serum estrone concentrations (17).
M2 PHARMA-January 2, 2018-FDA Approves Mylan Generic for Estrace Cream
It currently markets two products in Canada: ESTRACE, a product indicated for the symptomatic relief of menopausal symptoms; and NATESTO, a testosterone nasal gel for testosterone replacement therapy in adult males diagnosed with hypogonadism.
Some of the drug that are administered orally are Premarin and Estrace.