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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
ELVANSE (lisdexamfetamine dimesylate) ESTRACE (trademark of Trimel
Underlying sales jumped 57 per cent to $89m, driven in part by a 39 per cent growth in the company's top products, such as Ovcon contraceptive pills, Estrace hormone replacement cream and acne treatment Doryx.
Speciality drugs company Galen's focus on niche areas such as women's healthcare should be boosted in the US market by the pounds 67 million purchase of Estrace tablets.
Roberts Pharmaceutical Canada has a strong presence in women's healthcare, with currently marketed products including: ESTRACE, an estrogen-only hormone replacement therapy, REPLENS, a vaginal moisturizer, and ADVANTAGE 24, a nonoxynol-9 spermicidal gel.
Estrogen-replacement drugs such as Premarin, Ogen, and Estrace, approved in 1988.
Estrace cream (estradiol) by Warner Chilcott and Premarin cream (conjugated estradiol) by Pfizer are examples of vaginal creams, while Vagifem (estradiol) is a vaginal tablet and is marketed by Novo Nordisk.
The United States Department of Justice announced today that pharmaceutical manufacturer Warner Chilcott has agreed to plead guilty to health care fraud and pay $125 million to resolve civil and criminal liability arising from the illegal promotion of the drugs Actonel, Asacol, Atelvia, Doryx, Enablex, Estrace, and Loestrin, and various formulations of these drugs.
9 million) following the divestment of CALCICHEW, VANCOCIN, ESTRACE and EXPUTEX.