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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
According to the company, Estrace Cream is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.
Estrace cream or Premarin cream will burn if applied to skin affected by lichen sclerosus because they contain alcohol.
Because Natural Hormones act gently, women do not experience side-effects associated with synthetic replacement therapies like Premarin, Provera, Estrace Prempro, etc.
USD 3m was available at closing, with the remaining USD 2m becoming available upon satisfaction of certain future conditions, including our US Partner for Natesto achieving a set number of prescriptions per month, and maintaining Estrace sales at a set minimum level.
6bn, reflecting, among other things, the anticipated growth of its promoted products in the US, primarily LO LOESTRIN FE, ATELVIA, ESTRACE CREAM and ASACOL.
5 g daily conjugated estrogen) for 3 weeks; then, twice weekly (Note: Dosage can be increased to 2 g daily but this may require progesterone supplementation) Estrace 0.
Products approved by the FDA for menopausal symptoms include those containing the identical 17-beta-estradiol (such as Estrace tablets and vaginal cream, all estrogen skin patches, and new topical gels, such as Estrasorb).
With counselling from my doctor, I decided to go on hormones, 1 mg Estrace and 100 mg Prometrium.
TABLE 2 Drug theraphy for prevention and treatment of postmenopausal osteoporosis Drug Indication and dosage (trade name) Calcium and vitamin D Prevention and treatment: (generic, Tums, Citracal, 1200-1500 mg/day calcium and others) and 800 IU/day vitamin D Estrogen ([dagger]) Prevention: (Premarin, Ogen, Estrace, 0.
I explain to patients that estradiol--the medication in Estrace, Vivelle, etc.
They include the three estrogens (estradiol, estriol, and estrone in products such as Estrace, Vivelle, Climara, and Estraderm patches) and micronized progesterone (such as Prometrium and Crinone vaginal gel).
I use Estrace cream as one of your readers explained.