Estradiol


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estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
In a safety evaluation study of these treatments performed at an academic US cancer center, Melisko and colleagues randomly assigned postmenopausal women with hormone receptor-positive breast cancer who reported vaginal dryness, sexual pain, or reduced sexual desire to 12 weeks of off-label treatment with an estradiol vaginal ring or intravaginal testosterone cream.
Table II: Association between BMI and estradiol levels in premenopausal and postmenopausal breast cancer patients and controls.
Results from this study demonstrated that a sudden increase in estradiol concentrations was observed after administration of PGF2?
In other research, estradiol protected the brain from injury, including stroke, lipid peroxidation, oxidative damage, and beta amyliod toxicity.
Para efectos del analisis de la informacion, los niveles de estradiol fueron categorizados en dos grupos, en base a la concentracion de estradiol en el dia de la monta, segun el reporte en camellos de Deen et al.
In addition, the present data revealed an inverse correlation between serum estradiol level and BMI.
The day this study was published, Life Extension[R] wrote the doctors who conducted it asking if there were any data regarding baseline and post-baseline blood estradiol levels.
Reductions in ambulatory blood pressure showed findings similar to clinic readings, although the combination with 1 mg of drospirenone also had marginal benefits compared with placebo and estradiol alone, he added.
The researchers gave half the birds tiny implants that released estradiol, which normally abounds in females during breeding season.
The second study focused on this response following injection of estradiol and bisphenol A, alone and in combination, into rat cerebella.
Humans make estriol, estradiol and estrone, and some compounding pharmacies (which make individualized prescriptions) and alternative medicine providers are touting bioidentical versions of these hormones as harmless alternatives to conventional hormone therapy.
The direct measurement of serum estradiol offers advantages over the more traditional sample extraction and immunoassay methods with respect to technical ease of the assay and turnaround time.