Estradiol


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estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
Collectively, the data provide the first evidence that the rapid signaling initiated by such interactions is essential for estradiol to enhance memory regulated by the hippocampus.
Reasons for Switching The survey showed that for the majority of all respondents (52 percent), the switch to estradiol vaginal tablets was recommended by the patient's healthcare professional.
6), (7) Thus beginning estradiol during the menopausal transition is likely to delay the onset of dementia, and may prevent AD in many women.
If elderly men are prescribed large doses of topical testosterone gel or cream, their estradiol blood levels have to be tested and properly controlled.
DeKeyser's second question, generally speaking, circulating estradiol in premenopausal women is greater than 150 pmol/L or greater than 40 pg/mL.
The blood pressure-lowering effect of estradiol (-7.
Not only are the doses many magnitudes lower than those considered in classic high-dose toxicity studies, but at extremely low doses both estradiol and bisphenol A demonstrate a response that disappears as the dose increases.
In fact, studies consistently show that women who have naturally occurring higher levels of estradiol and estrone in their bodies develop breast cancer more often than women with lower levels of-estrogens.
The direct measurement of serum estradiol offers advantages over the more traditional sample extraction and immunoassay methods with respect to technical ease of the assay and turnaround time.
Women with estradiol levels in the highest third had significantly smaller hippocampal volumes determined by MRI scans than women with levels in the lowest third.
Elestrin is absorbed through the skin after topical application on the upper arm, and delivers estradiol to the bloodstream evenly over time in a non-irritating, painless manner.
Using mice, Relloso and colleagues found that the sex hormone, estradiol, increased susceptibility to systemic candidiasis (fungal infection).