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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
5 [micro]g of estradiol acetate per day, a dosage that's effective for vaginal symptoms but not for systemic menopausal symptoms.
In the study, 333 naturally and surgically postmenopausal women with moderate to severe vasomotor symptoms were randomly assigned to receive a placebo ring or one of two active therapy rings that released either 50 or 100 [mu]g day of estradiol acetate, said Dr.
Galen Holdings PLC , the international pharmaceutical company, announced today that it has received an approvable letter for its estradiol acetate intra-vaginal ring from the Food and Drug Administration (FDA) in the US.