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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
2] 7 days later and AI at estrus; Ovsynch (GnRH, followed by PGF2 7 days later, then 2 days later GnRH followed by a timed AI 12 h later) as OV3, OV6 and OVE, which correspond to the injection of the first GnRH on day 3, 6 and 6 of the estrous cycle, respectively, but OVE also received an injection of 0,5 mg of estradiol cypionate 36 h before the timed AI.
Effects of estradiol cypionate on ovarian follicular dynamics, synchrony of ovulation, and fertility in CIDR-based, fixedtime AI programs in beef heifers.
The objective of this work was to evaluate the effect of two doses of estradiol cypionate (ECP) and two intervals for insemination upon pregnancy rate at FTAI.
Lunelle combines 25 mg of medroxyprogesterone acetate and 5 mg of estradiol cypionate in 0.
Lunelle is a combination of 25 mg of medroxyprogesterone acetate and 5 mg of estradiol cypionate contained in 0.