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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
Effect of two doses of estradiol cypionate and hourly rank for FTAI on pregnancy rate in heifers.
Use of estradiol cypionate in a presynchronized timed artificial insemination program for lactating dairy cattle.
CFHC), today announced it was advising all of its delegate health agencies of the voluntary recall of the Lunelle Monthly Contraceptive injection (medroxyprogesterone acetate and estradiol cypionate injectable suspension) by the Pharmacia Corporation, and urging the health clinics to immediately halt the use of the product until further notice.