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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
SHAM 1 = sham-operated rats treated with vehicle as normal control 1; SHAM 2 = sham-operated rats treated with vehicle as normal control 2; OVX= ovariectomized rats treated with vehicle as negative control; PIR = ovariectomized rats treated with piracetam at the dose of 1.5 mg/kg BW as positive control 1; E2V = ovariectomized rats treated with estradiol valerate at the dose of 1 mg/kg BW as positive control 2; FU 50 and 200 = ovariectomized rats treated with F.
Therefore, reported observation confirmed the creation of the cyst and stopping of follicular development after 60 days of treatment with estradiol valerate, due to lack of normal ovulation, cyst formation and normal follicular growth distribution (Figure 1).
E2V = OVX animals treated with 1 mg/kg of estradiol valerate; Lannea acida = OVX animals treated with ethanol extract of Lannea acida at doses of 50 and 200 mg/kg BW.
After 2 weeks of sustained estradiol valerate administration, PGP 9.5-ir innervation in both the distal- and proximal-half areas was increased (by varying degrees) over that in the OVX rats (P < 0.001 for both areas; Figures 1 and 2(b), Table 2).
Eight of the forty rats were underwent bilateral laparotomy without removing the ovaries as Sham control group, while the remains were underwent bilateral ovariectomy and equally randomized into four groups: orally administered vehicle (0.5% CMC-Na) as model group (OVX), estradiol valerate (1 mg/kg body weight/day) as positive control (EV), 8 and 16 mg/kg body weight/day of KN as low (KL) and high (KH) dosage groups, respectively.
Exposure of adult rats to estradiol valerate induces ovarian cyst with early senescence of follicles.
Natazia has not been evaluated in women with a BMI of greater than 30 kg/m(2), the company added and further said that Natazia is the first and only oral contraceptive that contains an estrogen called estradiol valerate and a progestin called dienogest.
The PRO treatment consists of an ear implant that contains norgestomet (6 mg) and an intramuscular injection of estradiol valerate (5 mg) and norgestomet (3 mg) mixed together.
In one study, (10) 41% of menopausal women taking either conjugated equine estrogen, 1.25 mg, or estradiol valerate, 4 rag, daily reported persistence of hot flashes, and 35% had significant night sweats.
In the control group with oral route (22) (n=45), at the time of cycle, 6 mg of oral estradiol valerate (Aburaihan, Iran) was started daily.
foetida extract in Group A, estradiol valerate and medroxyprogesterone acetate in Group B, and estradiol valerate and progesterone in Group C.