SHAM 1 = sham-operated rats treated with vehicle as normal control 1; SHAM 2 = sham-operated rats treated with vehicle as normal control 2; OVX= ovariectomized rats treated with vehicle as negative control; PIR = ovariectomized rats treated with piracetam at the dose of 1.5 mg/kg BW as positive control 1; E2V = ovariectomized rats treated with estradiol valerate
at the dose of 1 mg/kg BW as positive control 2; FU 50 and 200 = ovariectomized rats treated with F.
Therefore, reported observation confirmed the creation of the cyst and stopping of follicular development after 60 days of treatment with estradiol valerate
, due to lack of normal ovulation, cyst formation and normal follicular growth distribution (Figure 1).
E2V = OVX animals treated with 1 mg/kg of estradiol valerate
; Lannea acida = OVX animals treated with ethanol extract of Lannea acida at doses of 50 and 200 mg/kg BW.
After 2 weeks of sustained estradiol valerate
administration, PGP 9.5-ir innervation in both the distal- and proximal-half areas was increased (by varying degrees) over that in the OVX rats (P < 0.001 for both areas; Figures 1 and 2(b), Table 2).
Eight of the forty rats were underwent bilateral laparotomy without removing the ovaries as Sham control group, while the remains were underwent bilateral ovariectomy and equally randomized into four groups: orally administered vehicle (0.5% CMC-Na) as model group (OVX), estradiol valerate
(1 mg/kg body weight/day) as positive control (EV), 8 and 16 mg/kg body weight/day of KN as low (KL) and high (KH) dosage groups, respectively.
Exposure of adult rats to estradiol valerate
induces ovarian cyst with early senescence of follicles.
Natazia has not been evaluated in women with a BMI of greater than 30 kg/m(2), the company added and further said that Natazia is the first and only oral contraceptive that contains an estrogen called estradiol valerate
and a progestin called dienogest.
The PRO treatment consists of an ear implant that contains norgestomet (6 mg) and an intramuscular injection of estradiol valerate
(5 mg) and norgestomet (3 mg) mixed together.
In one study, (10) 41% of menopausal women taking either conjugated equine estrogen, 1.25 mg, or estradiol valerate
, 4 rag, daily reported persistence of hot flashes, and 35% had significant night sweats.
In the control group with oral route (22) (n=45), at the time of cycle, 6 mg of oral estradiol valerate
(Aburaihan, Iran) was started daily.
foetida extract in Group A, estradiol valerate
and medroxyprogesterone acetate in Group B, and estradiol valerate
and progesterone in Group C.