Estradiol

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Related to Estring: Vagifem, Femring

estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
"The Estring had continuous absorption throughout the entire 3-month period.
Combine it with the Estring for even more lubrication.
Until the availability of Estring, treatment options included estrogen tablets, transdermal patches, and vaginal creams.
For stress UI, treatment options include topical estrogen or Estring (but not oral estrogen), [alpha]-adrenergic agents such as pseudoephedrine, and imipramine, which may be particularly helpful for combined urge and stress incontinence.
Bill Growdon of Santa Monica, Calif., notes that the Estring estrogen ring can be difficult and painful to remove from a patient with urogenital atrophy and a stenotic introitus.
Vaginal estrogen is available as a cream (Premarin, Estrace), a tablet (Vagifem) and a flexible plastic ring (Estring).
A similar device, Estring, is approved for treating urogenital symptoms associated with postmenopausal atrophy of the vagina or lower urinary tract.