Estrone


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Related to Estrone: estriol

estrone

[′e‚strōn]
(biochemistry)
C18H22O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; functions the same as estradiol.

Estrone

 

C18H22O2, a female sex hormone of the estrogen group. Estrone occurs as colorless crystals with a melting point of 259°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +170°.

Estrone was first isolated in 1929 from the urine of pregnant women by A. Butenandt and the American biochemist E. Doisy. Specific sources rich in the hormone are the urine and testes of stallions. The hormone is readily converted both metabolically and chemically into estradiol, a hormone that has higher estrogenic activity. Estrone is found not only in animals and humans, but also in certain fruits, such as the coconut, apple, and pomegranate. Because its structure is so simple, many methods for the complete chemical synthesis of estrone have been developed. The most economical of these was suggested by the Soviet scientist I. V. Torgov in 1962.

Estrone has important physiological functions (see).

References in periodicals archive ?
Group 2 consisted of pharmaceuticals and personal care product compounds, including ketoprofen, ibuprofen, bezafibrate, triclosan, and chloramphenicol, and were analysed in negative ESI mode, while Group 3 was composed of the steroid hormones, namely, estrone, estriol, 17[beta]-estradiol, and 17[alpha]-ethinylestradiol (EE2), which were analysed separately in negative ESI mode.
(2002) stated that in vitro callus culture of immature wheat embryos is strongly stimulated by androsterone but regeneration is similar to control estrone and progesterone inhibits the first leaf and a callus growth of immature embryos in in vitro culture.
In conclusion, using estrone and pregnenolone as starting materials, through different chemical methods, some steroidal copper (II) complexes were synthesized and characterized by IR, NMR, and HRMS.
"Instead of converting the estradiol into 2 OH estrone, the body might convert it into 4 OH estrone instead, which can lead to free radical formation and cancer.
The low testosterone and androstenediol glucuronide, high androstenedione and estrone levels are consistent with testosterone synthetic defect due to 17-[beta]-HSD3 deficiency.
In this context, current paper determines the level of concentration of the following FSHs: estrone (E1), 17 [beta] estradiol (E2), 17 [alpha] ethinylestradiol (EE2) and progesterone (Pg) in the Iguazu River Basin in Curitiba, south Brazil, and relate them to limnological parameters that indicate contamination by domestic sewage discharges.
Estradiol and estrone are part of the mix of hormones commonly implanted into cattle to enhance growth and these contribute to our estrogen intake.
A solution of estrone (100 mg, 0.37 mmol) and tert-Butyldimethylsilyl chloride (200 [micro]L, 1.07 mmol) in 5 mL of methanol was stirring for 8 h at room temperature (Figure 2).
This fact is attributed to an increased peripheral production of estrone through increased aromatization of androstenedione by aromatase in the white adipose tissue [8, 9].
The estrogens in women are estrone (E1), estradiol (E2), and estriol (E3).
An expanding amount of research suggests that effluents from domestic wastewater treatment plants (WWTP) can contain natural (estrone, El; 17[beta]estradiol, E2; and estrone, E3) and synthetic (17[alpha]-ethinylestradiol, EE2) estrogens (see Limpiyakorn et al.