Estrone


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Related to Estrone: estriol

estrone

[′e‚strōn]
(biochemistry)
C18H22O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; functions the same as estradiol.

Estrone

 

C18H22O2, a female sex hormone of the estrogen group. Estrone occurs as colorless crystals with a melting point of 259°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +170°.

Estrone was first isolated in 1929 from the urine of pregnant women by A. Butenandt and the American biochemist E. Doisy. Specific sources rich in the hormone are the urine and testes of stallions. The hormone is readily converted both metabolically and chemically into estradiol, a hormone that has higher estrogenic activity. Estrone is found not only in animals and humans, but also in certain fruits, such as the coconut, apple, and pomegranate. Because its structure is so simple, many methods for the complete chemical synthesis of estrone have been developed. The most economical of these was suggested by the Soviet scientist I. V. Torgov in 1962.

Estrone has important physiological functions (see).

References in periodicals archive ?
Estrone production during pregnancy is lower than that of estriol and estradiol, and its levels do not correlate with the other estrogens; neither is its function during pregnancy well understood (Braunstein 2003).
Estrone binds preferentially to ER [alpha], whereas estriol binds to ER [beta].
While the extract of pregnant mares urine known as Premarin does contain one human estrogen, estrone, it also contains numerous equine estrogens foreign to human physiology.
Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma.
Other sources of endogenous estrogens These sources include fat cells converting the androgens androstenedione and testosterone into estrone and estradiol, respectively, as well as estrogen-producing tumors.
This increase may be attributed to impaired estradiol metabolism, with decreased conversion of estradiol to estrone (Purohit 2000).
When I talk about estrogens, I'm talking about the three major estrogen compounds found in our bodies: estrone, estradiol, and estriol.
In her book, Estrogen the Natural Way, author Nina Shandler explains that there are three types of estrogen: estradiol, estrone and estriol, arranged from strongest to weakest.
levels of estradiol and estrone increase prior to and during ovarian and testicular maturation.
Fiber has the ability to interrupt estrogen pathways, decreasing the blood levels of estrone sulfate, the most prevalent form of estrogen.
This is what I have found as a veterinarian and would like to share; unfortunately, most medical education only teaches testing for estradiol, estrone, and estrin in women, and estradiol in men.