Ethisterone


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Ethisterone

 

(in Russian, pregnin), a synthetic medicinal agent belonging to the group of hormonal preparations. Ethisterone is taken orally for disturbances of ovarian function; it has the biological and therapeutic properties of the natural hormone of the corpus luteum.

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Randomised trial of high doses of stilbestrol and ethisterone therapy in pregnancy: long-term follow-up of the children.
We purchased testosterone, epitestosterone, 5[alpha]-dihydrotestosterone, dihydroepiandrosterone, androstenedione, estrone, androsterone,19-hydroxytestosterone, ethisterone, cyproterone acetate, ammonium acetate (SigmaUltra), and zinc sulfate heptahydrate from Sigma-Aldrich; HPLC gradient-grade methanol and water from Fisher Scientific; ACS reagent-grade ethanol from Hayman Ltd.; formic acid (Aristar) from BDH Laboratory Supplies; diethyl ether from Vickers Laboratories Ltd.; dideuterated testosterone {[1,2-[sup.2]H]testosterone ([D.sub.2]T); chemical purity by HPLC >99%; mass purity, 99.7%; product code D-29621 from [Qm.sub.x] Laboratories Ltd.; and double charcoal-stripped serum from SCIPAC Ltd.
The remaining steroids tested, epitestosterone, dihydrotestosterone, dehydroepiandrosterone, androsterone, 19-hydroxytestosterone, ethisterone, and cyproterone acetate, showed no significant peaks above background noise.