5 billion years, these genes have given rise to the genes that exist today through two major evolutionary mechanisms: duplication and divergence, and exon shuffling.
Exon shuffling is another major evolutionary mechanism.
The paper, entitled, "Multivalent Avimer(TM) Proteins Evolved by Exon Shuffling
of a Family of Human Domains," was published in the on-line version of Nature Biotechnology.
for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling
, in which multiple different product molecules are produced in a single ligation reaction.
I do not discuss the mechanics of gene duplication or exon shuffling
which are the main means by which new molecules arise (Graur and Li, 2000).
The work supports the exon shuffling
theory, which contends that introns act as spacers where breaks for genetic recombination occur.