exonuclease

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exonuclease

[¦ek·sō′nü·klē‚ās]
(biochemistry)
Any of a group of enzymes which catalyze hydrolysis of single nucleotide residues from the end of a deoxyribonucleic acid chain.
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To optimize lambda exonuclease reaction, 5 pg of the purified dsDNA was incubated with 5 U lambda exonuclease in a total reaction volume of 30 [micro]l in a reaction buffer at 37[degrees]C.
Results of dsDNA digestion by lambda exonuclease at different incubation times were analyzed on the 10% denaturing-urea PAGE (Figure 6).
The associated 5'-3' exonuclease activity of the DNA polymerase makes possible the synthesis of extension products derived from upstream primers even in the presence of downstream primers.