gene expression

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gene expression

[′jēn ik¦spresh·ən]
(genetics)
The transcription, translation, and phenotypic manifestation of a gene.
References in periodicals archive ?
The study shows that psychopathy is associated with robust alterations in the expression of genes and immune-response-related molecular pathways.
Other mechanisms do control the first step of expression of genes. In cells of higher organisms (humans, yeast, etc.), the DNA is tightly bound to a set of proteins called histones to form a compact body called chromatin.
Gene Set Analysis (GSA) showed significant expression of genes in five and nine KEGG orthology (KO) pathways in BR7 and BR21, respectively (Figure 2).
BMM had increased expression of genes associated with aerobic glycolysis, nitric oxide production, branched-chain amino acid metabolism, and fatty acid [beta]-oxidation as well as decreased expression of genes associated with cholesterol biosynthesis.
We detected a higher expression of gene Ae1 in antler mesenchyme of male reindeer, and there were two conjectures: the male maybe need a higher expression of gene Ae1 to regulate cell carcinogenesis, and the antler of male reindeer may grow faster than the female.
We also demonstrated that expression of genes encoding proteins implicated in extracellular matrix (ECM) remodeling including matrix-metalloproteinase 1 (MMP1), fibroblast activated-protein (FAP), dipeptidyl peptidase IV (DPP4), and transforming growth factor [beta]1 (TGF[beta]1) was significantly upregulated during the dedifferentiation process [2].
To test the ability of BMMSCs, Ad-MSCs, and LSCs to express genes for the basic immunoregulatory molecules, the cells were cultured for 48 hours unstimulated or stimulated with LPS and the expression of genes for IDO-2, iNOS, and Cox-2 was determined by real-time PCR.
Bioinformatics has made making sense of large amounts of biological data possible; techniques like RNA-seq data analysis allow researchers to examine differential expression of genes and discover novel genes, transcripts and transcriptomes.
Michael Holick, concluded that, "Our data suggest that any improvement in vitamin D status will significantly affect expression of genes that have a wide variety of biologic functions of more than 160 pathways linked to cancer, autoimmune disorders, and cardiovascular disease, which have been associated with vitamin D deficiency.
These quantities and their associated statistical significance can be computed from collections of expression of genes with number of samples 250 or greater.
Chromatin remodeling is a major factor in epigenetics 6 how environmental conditions can influence the expression of genes.
A study carried out by researchers at the National Institutes of Health and colleagues found that, unlike many other cell growth regulators, MYC does not turn genes on or off, but instead boosts the expression of genes that are already turned on.