actin

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Related to F-actin: phalloidin, G-actin, Vinculin

actin,

a protein abundantly present in many cells, especially muscle cells, that significantly contributes to the cell's structure and motility. Actin can very quickly assemble into long polymer rods called microfilaments. These microfilaments have a variety of roles—they form part of the cell's cytoskeleton, they interact with myosinmyosin
, one of the two major protein constituents responsible for contraction of muscle. In muscle cells myosin is arranged in long filaments called thick filaments that lie parallel to the microfilaments of actin.
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 to permit movement of the cell, and they pinch the cell into two during cell division. In muscle contraction, filaments of actin and myosin alternately unlink and chemically link in a sliding action. The energy for this reaction is supplied by adenosine triphosphateadenosine triphosphate
(ATP) , organic compound composed of adenine, the sugar ribose, and three phosphate groups. ATP serves as the major energy source within the cell to drive a number of biological processes such as photosynthesis, muscle contraction, and the synthesis of
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.

actin

[′ak·tən]
(biochemistry)
A muscle protein that is the chief constituent of the Z-band myofilaments of each sarcomere.
References in periodicals archive ?
Fluorescence microscopic studies showed the effect of nicotine (1 uM and 10 uM) on F-actin distribution in the A549 cells.
Moreover, the result of F-actin staining illustrated that Nec-1 significantly decreased the augment of cell surface area induced by PA, as shown in Figure 1(d).
F-actin staining has revealed that the sinuses contain numerous actin filaments that span the entire length and width of the light organ appendages, in a manner suggestive of muscle fibers (Fig.
These IC are maintained by a number of different proteins, such as CD31 and f-actin (Fig.
2+], gelsolin severs and caps polymeric actin filaments (F-actin) (21): after binding of domain G1 and partly domain G2 to the actin filament (F-actin), gelsolin rapidly severs F-actin and then remains bound to the barbed end of one of the newly formed filaments, forming a stable cap, thus inhibiting addition of further monomers.
Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.
1981) Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin.
G- and F-actin are constituents of myofibrils, which are small membraneless parallel fibers in muscle (Murray, 1995).
Cells were incubated with rhodamine phalloidin (1: 50; Molecular Probes, USA) to label F-actin and with DAPI (1 [micro]g/mL, Sigma-Aldrich, USA) to label nucleic acid, for 20 min at RT.