ligand

(redirected from FASL)
Also found in: Dictionary, Thesaurus, Medical, Acronyms.
Related to FASL: Fas protein, Fas receptor

ligand

ligand (lĭgˈənd), charged or uncharged molecule with one or more unshared pairs of electrons that can attach to a central metallic atom or ion to form an aggregate known as a complex ion (see chemical bond). Some ligands that share electrons with metals form very stable complexes. Some common bases that act as ligands are water and ammonia molecules and halide, hydroxide, acetate, cyanide, thiocyanate, and nitrite anions. These ligands are monofunctional, i.e., they are attached by one unshared pair of electrons during complexing. Polyfunctional ligands, which bind to the metal ion with two or more pairs of electrons, are called chelates (see chelating agents). Ethylenediamine-tetraacetate, a commonly used chelating compound, has six pairs of electrons to bind to metal ions. Electron-donating functional groups containing nitrogen, oxygen, sulfur, phosphorous, or carbon may act as ligands in complex biological systems. For example, in enzymes that need complexed metal ions to function, mercapto (sulfur-containing) groups and amino (nitrogen-containing) groups act as chelating agents; these groups fix the metal ion in a specific position. Other biologically important molecules, such as chlorophyll, vitamin B12, and heme, also have nitrogen-containing groups that donate electrons and have a chelating function.
The Columbia Electronic Encyclopedia™ Copyright © 2022, Columbia University Press. Licensed from Columbia University Press. All rights reserved.

ligand

[′lī·gənd]
(chemistry)
The molecule, ion, or group bound to the central atom in a chelate or a coordination compound; an example is the ammonia molecules in [Co(NH3)6]3+.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Given the involvement of both MMP-9 and -2 in FasL shedding, we next examined whether the AREG-mediated increase in both gelatinases indeed induces shedding of memFasL.
On the other hand, BDE-47 increases the expression of FAS, FASL, and caspase-8, starting up an extrinsic pathway.
FasL [0,1] FasL * 0 Casp8 [0,1] Casp8 * 0 Casp3 [0,1] Casp3 * 0 Apop 0 Bid [0,1] tBid 0 DNA [0,1] DNAdamage 0 ATR [0,1] ATR * 0 p53 [0,1] p53 * 0 Bax [0,1] BCl2 [0,1] Cytcmit [0,1] Cytc 0 Casp9 [0,1] Casp9 * 0 granB [0,1] granB * 0 Casp10 [0,1] Casp10 * 0 FasL *.Casp8 0 Casp8 *.Casp3 0 ATR *.p53 0 p53 *.Bax 0 Bax.Bak 0 p53 *.BCl2 0 BCl2.Bax 0 Cytc.Casp9 0 Casp9 *.Casp3 0 granB * .Casp10 0 Casp10 *.Casp3 0 Casp8 *.Bid 0 tBid.Bax 0 granB * .Bid 0 All values are in nondimensional form.
(7) It is found more than perforin/granzyme B and soluble FasL in SJS/TEN patients' blister (2-4 times more).
Fasl is a Graduate Research Assistant and Andrew G.
The aim of this study was to evaluate the expression of proteins: FHIT, E-cadherin, [alpha]-catenin, [gamma]-catenin, cathepsin B, EGF, HER-2, MMP-9, MCM-2, Bak, Bax, BID, Bcl-XL, p53, FasL, Bcl-2, caspase-8, procaspase-3 in gastric cancer cells, depending on the type of tumor by Lauren classification.
Natural substance connected with Fas protein its ligand (FasL) belongs to the TNF[alpha] group (Poradin, Salmasi, Cazimirskiy, 2006).
In these studies, we found that IL-12 inhibited TNF-[alpha]-mediated osteoclastogenesis by inducing apoptotic changes in osteoclast precursor cells through interactions between TNF-[alpha]-induced Fas and IL-12-induced FasL. We also investigated whether IL-12 inhibits mechanical tooth movement.
However, both concentrations of TCE did suppress expression of Fasl, the gene that encodes for the ligand for Fas, and an important mediator of activation-induced apoptosis.
Additionally, mutations in cytokine receptors and costimulatory molecules, such as CD28/B7 [13], and polymorphisms in genes associated with apoptosis, such as Fas, FasL, and Bcl-2, have been implicated in disease pathogenesis [14].