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In the present study, we aimed to evaluate the prognostic significance of FGFR1 in patients with gastric cancer, and the mechanism of miR-497-regulated FGFR1 in gastric cancer cell proliferation and apoptosis.
It was determined that FGFR1 amplification had an incidence of 21% in squamous cell carcinoma, and it was also associated with a low survival rate and a history of smoking.
(a) The inhibition of FGFR1 promoted the differentiation.
Guo, "MiR-361-5p inhibits glycolytic metabolism, proliferation and invasion of breast cancer by targeting FGFR1 and MMP1," Journal of Experimental & Clinical Cancer Research, vol.
Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family.
A sarcoidosis-like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification.
Genes that show amplification include erb-b2 receptor tyrosine kinase 2 (ERBB2),which can be treated with anti-human epidermal growth factor receptor 2 (HER2) agents such as trastuzumab, cyclin D1 (CCND1), fibroblast growth factor receptor 1 (FGFR1) and v-myc avian myelocytomatosis viral oncogene homolog (MYC) (6).
Other studies have found that FGF1 may be exerting its insulin-sensitizing activity through the FGF1 receptor (FGFR1) in adipose tissue, although it can bind and activate all alternatively spliced forms of the four tyrosine kinase FGF receptors (FGFR1-FGFR4).
When the FGF receptor 1 (Fgfr1) is genetically deleted in the inner ear, the number of proliferative prosensory cells decreases resulting in decreased number of HCs and SCs [63, 64].
Pathology Genes Orofacial clefts CL/P BMP4 CRISPLD2 FGF8 FGFR1 FGFR2 FOXE1 GLI2 GSTM1 GSTT1 JAG2 LHX8 MSX1 MSX1 MSX2 NAT1 NAT2 PTCH PVRL1 RYK SATB2 SKI SPRY2 TBX10 TGFB3 ATM Papillary thyroid cancer NKX2 RET (RET/PTC rearrangement) DFNB31 Hypothyroidism PTPN22 SH2B3 VAV3
Apart from the 3 mutants with only spina bifida (Fgfr1, Shp2, and Gcm1) which have 2 neural tubes with one notochord, 2 other mutants with spinal defect but no spina bifida share the same predicament.
FGFR1 in colon tissue homogenates of all Garidisan dose groups were elevated compared with the UC model group (P < 0.05).
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