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frt

Abbr. for “freight.”
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References in periodicals archive ?
The key nodes include VEGFA, KDR, and FLT1, which indicated that these proteins may have a critical role in PDR and the mechanisms of the effect of IVC.
As reported in Table 2, 14 genes (KRT19, FLT1, EGER, EPCAM, MET, PGR, CD24, KIT, PLAU, ALDH1A1, CTSD, MKI67, TWIST1, and ERBB2) were evaluated as significantly differentially expressed in the tested sample cohorts between CTC+ and CTC- samples.
Both ADAM10 and ADAM17 were responsible for ectodomain shedding of Flt1. We found that ADAM17 was expressed in adipocytes whereas ADAM10 was not expressed in adipocytes through PCR assay and Western blotting assay (data for ADAM10 was not shown).
Bautch, "Blood vessel anastomosis is spatially regulated by Flt1 during angiogenesis," Development, vol.
Charnock-Jones, "Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling," Cardiovascular Research, vol.
Otherwise, the expression of VEGFR1 (Flt1) was not affected by the treatment.
Lenvatinib, discovered and developed by Eisai, is an oral multiple receptor tyrosine kinase (RTK) inhibitor with a novel binding mode that selectively inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors (VEGFR1 (FLT1), VEGFR2 (KDR) and VEGFR3 (FLT4)), in addition to other proangiogenic and oncogenic pathway-related RTKs (including fibroblast growth factor (FGF) receptors FGFR1, 2, 3 and 4; the platelet-derived growth factor (PDGF) receptor PDGFRalpha; KIT; and RET) involved in tumor proliferation.
Based on gene expression direction of 14 genes, namely CCR2, CXCL6, DACT2, ELF5, ENAH, ESR1, FLT1, LIN28B, NCAM1, NOX4, SERPINA1, TLE1, TLR7, XRCC5, it can be concluded that Rhodiola may have beneficial effect in cancer, that is in line with growing body of evidence about antitumor activity of Rhodiola and salidroside [Cai et al., 2012; Zhang et al., 2013; Liu et al., 2012; Bocharova et al., 1995; Dement'eva and laremenko, 1987].
Using the K5-SOS transgenic mouse model, in which mice develop skin tumors spontaneously or after a skin wound, it has been shown that epidermal tumor cells of K5-SOS transgenic mice express high levels of VEGF and its receptors Flt1 and Nrp1 [91].
In LvM442 network, the top node degree genes are STAT6, and the glycogene FLT1 (Figure 3(c)), both having the node degree of 13.
Carmeliet, "FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?" Nature Reviews Cancer, vol.