Moreover, a tumor suppressor protein recently described as immunoregulatory protein Fus1 has a role in the immune response to A.
Ivanova, "Loss of mitochondrial protein Fus1 augments host resistance to Acinetobacter baumannii infection," Infection and Immunity, vol.
Pathogenic proteins such as fused in sarcoma (FUS1
), transactive response DNA-binding protein 43 (TDP-43), and Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) are recruited into SGs [4,16-18].
The isolates showed a different response with both soilborn phatogen Fusarium culmorum (Fus1
) and Fusarium pseudograminearum (Fus 7).
Each sample was placed in three groups in the following order: The intact group, the one segment fusion group (C4-5; FUS1
), and the two segments fusion group (C4-5 and C5-6; FUS2; [Figure 1]).
However, to promote cancer activity, they also target different genes including C/EBP[beta], FOXO1, NFI-A, STAT5A, ARTN, FBXW7, and SEPT6 (for miR-223) [29-33] and FUS1
, RhoC, PTEN, CDKN1A, TGF[beta]R2, and NRF2 (for miR-93) [34-38].
: 2 x AAS(AC) + 2 x PSSM(SAN) + 4 x PSSM(PP) + PSSM(LHF.G) + PSSM(BGR) + PSSM(TGR) + SMR(PP) + SMR(BGR),
Lee et al., "Phase I clinical trial of systemically administered TUSC2(FUS1
)-nanoparticles mediating functional gene transfer in humans," Plos One, vol.
(2004) found NP-based gene therapy to be effective in systemic gene treatment of lung cancer using a novel tumor suppressor gene, FUS1
. Chitosan, a polymer long used in gene therapy, was reported to have increased transfection efficiency and decreased cytotoxicity (Mansouri et al.
Low levels of codon usage bias have also been observed in sex-related genes in Drosophila (Civetta and Singh, 1998) and in the Chlamydomonas mating-type locus genes Mid and Fus1
(Ferris et al., 2002).
(Austin, TX) announced that it has acquired the exclusive worldwide license for the fus1
gene from The University of Texas M.