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Related to Fab fragment: Fc fragment, phage conversion


(FABrication) A manufacturing plant that makes semiconductor devices. Many chips are created by "fabless" companies that take their tested designs to a fab for production, also called a "foundry. The U.S. has about 10-12% of the fabs in the world. See foundry.

Be the First on Your Block
You too can be a chip maker. All it takes is from $10 to $15 billion to build a state-of-the-art facility. See process technology.
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On drawings, abbr. for “fabricate.”
McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc.
References in periodicals archive ?
Each laboratory conducted proteomics studies on the Fab fragment of NISTmAb (PDB: 5K8A) [1-3] and performed three HDX-MS runs.
Using phage display we have isolated CD44v6-binding fully human Fab fragments that bind a defined peptide that overlaps with the epitopes of U36 and BIWA 1 [7] (Figure 2).
Hahne et al., "Bacterial production and functional characterization of the Fab fragment of the murine IgG1/[gamma] monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics," Protein Engineering, Design and Selection, vol.
All the MAbs reacted only with Fc, but not Fab fragments of their immunogens (Figure 5).
Although site-specific bioconjugation was made possible through recombinant Fab fragment production, the Fab fragments were not labeled through the thiol groups in the current study because one chelate per Fab fragment did not yield satisfactory signals.
Because the Fab fragment accounts for only one-third of the IgG molecule, the coating of wells can be more efficient, and the site-specific biotinylation ensures that the fragments are in the correct orientation and able to bind antigen.
According to the manufacturer, Digibind is a polyclonal mixture of antibody Fab fragments having a range of affinities, with dissociation constants (K.sub.d) ranging from [10.sup.-9] mol/L to [10.sup.-10] mol/L (1-0.1 nmol/L) (8).
Other clinical and emergency situations in which serum digoxin monitoring is recommended include: (a) in cases of digitalis intoxication, to determine the amount of antidote (Fab fragment) needed; (b) in suspected poisoning by ingestion of plants such as oleandrin, to confirm the presence of digitalis-like poisons; (c) in patients with decreased renal function, to adjust digoxin dosage; and (d) in cases when other drugs known to interact with digoxin pharmacokinetics (e.g., quinidine, amiodorone, verapamil) are coadministered.
Treatment includes decontamination, close cardiac monitoring, supportive care and digoxin-specific Fab fragments if it can be obtained.
Fc and Fab fragments were produced from several purified human myeloma proteins of the IgG isotypes, by papain digestion (17).