But these entities are rarely associated with Fallot's Tetralogy
, as far as the present case is concerned.
Teratogenic effect on the cardiovascular system has: alcohol (leads to more frequent formation of IVSD, open arterial duct, IASD), amfetamines (condition IVSD, transposition of great vessels), anticonvulsive preparations--hydantoin (conditions stenosis of pulmonary artery and aorta, aorta coarctation, open arterial duct) and trimethadione (transposition of great vessels, Fallot's tetralogy
, hypoplasia of heart left side), lithium (Ebshtein anomaly, tricuspid valve atresia, IASD), progestogens (Fallot's teralogy, complex CHD) (Belacon and Podzaicov, 1991; Djordjikiya et al., 2005).
One fetus showed hemorrhagic lesions and two others had germinolytic cysts (for an example of cysts in a fetus with Fallot's tetralogy
, see bottom figure, page 1, white arrows).
Elaine, from Penycraig, says: "I was born a blue baby and my parents discovered I had something called Fallot's tetralogy
. I spent most of my early years in a pram as I was too weak to walk and it was only when I had pioneering heart surgery at nine, that I could walk without feeling exhausted.
Twelve patients had congenital heart disease, of which 6 patients had ASD, 4 patients had VSD, 1 patient had coarctation of aorta with bicuspid aortic valve and 1 patient had corrected Fallot's tetralogy
. Rest 28 patients (70%) had valvular heart disease, all of rheumatic origin.
For example, of 10 children operated upon for Fallot's tetralogy
, five survived.
Anomalous origin of the right pulmonary artery from ascending aorta is more frequent as a distinct anomaly, than the left pulmonary artery, but the latter is more often associated with Fallot's tetralogy
. Anomalous pulmonary artery branches usually arise from the ascending aorta.