Familial Mediterranean Fever

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familial Mediterranean fever

[fə′mil·yəl ¦med·ə·tə¦rā·nē·ən ¦ fē·vər]
A hereditary disease of unknown cause characterized by recurrent fever, abdominal and chest pain, arthralgia, and rash, sometimes terminating in renal failure. Abbreviated FMF. Also known as familial recurring polyserositis; periodic disease; periodic peritonitis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Familial Mediterranean Fever


(also benign paroxysmal peritonitis), a recurring, superficial aseptic inflammation of the serous membranes of the pleural part of the peritoneum, accompanied by heavy exudation. In most cases, the. disease arises before the age of 30. It is assumed to be a hereditary, recessive disturbance of metabolism that is probably autosomal; although men are affected more often than women, no sex-linkage has been shown. Other types of disturbances, including diencephalic and endocrine, are possibly involved.

The clinical picture of familial Mediterranean fever can take four forms. The abdominal form entails symptoms of acute abdomen, as a result of which almost half the patients with this form must undergo surgery. The thoracic form proceeds with a picture of dry or exudative pleuritis and with exudation inside the sinuses. The articular form resembles arthralgia or arthritis that affects one or more joints, and the remaining form is pseudomalarial.

Characteristic of all forms of familial Mediterranean fever are the chronic, recurring course and the serious condition during attacks that alternates with a sensation of complete health during the remissions of various duration. The attacks are typical and differ from each other only in severity and duration. They usually last from one to four days and leave no observable anatomical changes. All cases show similar nonspecific shifts in laboratory-test parameters, and the possibility of developing amyloidosis arises with 30–43 percent of patients. The amyloidosis leads to renal insufficiency and is associated neither with the frequency or character of the attacks nor with the duration of the disease. Treatment has little effect on the course of familial Mediterranean fever.


Oganesov, L. A., and V. M. Avakian. “Riad sluchaev neizvestnoi infektsionnoi bolezni.” Sovetskaia meditsina, 1938, no. 16, pp. 9–12.
Vinogradova, O. M. Periodicheskaia bolezn’. Moscow, 1973.
Siegal, S. “Benign Paroxysmal Peritonitis.” Annals of Internal Medicine, 1945, vol. 23, no. 1, pp. 1–21.
Siegal, S. “Benign Paroxysmal Peritonitis—Second Series.” Gastroenterology, 1949, vol. 12, no. 2. pp. 234–47.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The cutaneous manifestations in children with familial Mediterranean fever (recurrent hereditary polyserositis).
A new set of criteria for the diagnosis of familial Mediterranean fever in childhood.
Pras et al., "Clinical and diagnostic value of genetic testing in 216 Israeli children with familial Mediterranean fever," The Journal of Rheumatology, vol.
Cardiovascular reactivity score for the assessment of dysautonomia in familial Mediterranean fever. Rheumatol Int 2004;24:147-52.
(5.) Aoun EG, Musallam KM, Uthman I, Beydoun A, El-Hajj T Taher AT Childhood stroke in a child with familial Mediterranean fever carrying several prothrombotic risk factors.
Cattan, "MEFV mutation carriers and diseases other than familial Mediterranean fever: proved and nonproved association; putative biological advantage," Current Drug Target-Inflammation & Allergy, vol.
Sobel, "Amyloid goiter in familial Mediterranean fever," Clinical Endocrinology, vol.
In addition to ELANE mutation, our patient had positive finding of familial Mediterranean fever (MEFV).

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