Acute lymphoblastic leukemia in Fanconi's anemia
. Am J Hemat 1994;45:94.
Involvement of the Fanconi's anemia
protein FAC in a pathway that signals to the cyclin B/cdc2 kinase.
The recipient of the transplant was 6-year-old Matthew Farrow, who suffered from Fanconi's anemia
, a genetic blood disease that usually kills its victims by the age of 12.
Myles and Sancar's comprehensive 1989 review on DNA Repair pre-dates the recent breakthroughs in cloning the human genes for Fanconi's anemia
and several of the xeroderma pigmentosum complementation groups (reviewed by Barnes, Nature 359: 12-13, 1992).
The 5-year-old boy suffered from Fanconi's anemia
, an inherited aplastic anemia that depleted his marrow.
strikes only one child in 300,000, but the disease has a high profile in Eugene because University of Oregon President Dave Frohnmayer lost two daughters to the illness.