Our results showed that moderate-intensity training exercise decreased the abundance of FAS protein
, a marker of hepatic fibrosis.
The results are consistent with the study in rats, as niacin administration relieved the increased ACC and FAS protein
due to chronic renal failure in kidney (Cho et al., 2010).
The Fas receptor is located on the surface of the cell and is triggered by a ligand, which is a molecule that when produced fits into a complex receptor site on the Fas protein
, like a key fits into a lock.
Pursuing that possibility, their experiments would piece together the pathway of the genes to discover that the lupus mice had a malfunctioning Fas protein
that prevented their bone marrow mesenchymal stem cells from releasing a molecule needed for normal differentiation/bone formation.
The increasing expression of Fas protein
on the cells' surface induces interferon and TNF[alpha], and also activation of lymphocytes.
could increase intracellular [Ca.sup.2+] overload.
The Fas Protein
Expression Was Increased in Lupus Nephritis.
Treating the 3T3-L1 cells with 15 [mico]g/ml 6-gingerol decreased the FAS protein
levels by 26.8 [+ or -] 2.9 and 32.6 [+ or -] 3.3% compared to those from adipocyte controls on day 4 and 8 of differentiation, respectively (Fig.
Moreover, additional studies revealed that FAS protein
expression was three times higher in uterine fibroid samples compared to normal myometrial tissue (muscle tissue that forms the uterine wall).
To further investigate the potential role of ficolins in the preeclamptic trophoblasts, we demonstrated the strong expression of apoptotic protein marker Fas protein
, and also the coexpression of both ficolins and Fas in the syncytiotrophoblasts from established preeclamptic pregnancies (n = 5; Fig.
After the confirmation of the activated caspase-3, a marker of apoptosis development, and the elevated levels of active caspase-8 and Fas protein
, we did not observe increased levels of active caspase-9 or released cytochrome c in SHS-exposed rat hearts.
Sure enough, the genetically engineered mice appeared to manufacture healthy amounts of the normal Fas protein
. The team describes its work in the March 15 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES.