The presence of TNF[alpha] upregulates the Fas receptor
in the cells, and it brings about Fas-induced apoptosis.
The -670 polymorphism of the Fas receptor
was analyzed using PCR-RFLP analysis, as previously reported .
Various methods to inhibit apoptosis including the cell surface Fas receptor
(FAS) pathway inhibitors (also known as CD95L pathway inhibitor), caspase inhibitors, overexpression of anti-apoptotic genes and small interfering ribonucleic acid (RNA) therapy are discussed.
Having shown selective binding for misfolded Fas receptor
protein expressed on a number of tumor types, the company said it will now take a number of candidate antibodies into the next phase of development in an effort to evaluate their ability to effectively kill tumors in a number of cell based assays.
You need a special arrangement of Fas receptors
to trigger opening of the Fas death domain, and only then do you get activation.
in association with increased Fas receptor
This Fas receptor
can interact with the Fas ligand, which is present on the surface of certain T-cells.
(Rehovot, Israel) has patented proteins capable of modulating or mediating the FAS receptor
ligand or TNF effect on cells carrying FAS receptor
or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor
or to another protein TRADD which binds to the p55 receptor.
(CD95/APO-1) is a transmembrane protein that triggers apoptosis when stimulated with Fas ligand (FasL; CD95L).
One self-destruct button, a protein called Fas or Fas receptor
, sits on the surface of most cells in the body.
In the present report, we investigated the effects of apple Pcy on Fas receptor
expression and function in human colon adenocarcinoma SW480 cells and in their Fas-resistance derived metastatic SW620 cells.
The effects of [beta]-sitosterol on the extrinsic apoptotic programmed cell death pathway in human breast MCF-7 and MDA-MB-231 adenocarcinoma cells were examined, along with the extent of its incorporation into cellular membranes and its effects on cell growth, expression of Fas receptor
pathway proteins, and caspase-8 activity.