The other region, known as the fragment crystallizable or Fc region
, has demonstrated, in vitro, the ability to bind to immune cells that can play a role in killing tumor cells.
Our proprietary tools optimize the complete antibody structure, including the Fc region
to improve potency and half-life and variable region humanization and affinity optimization.
The VEGF Trap is a fusion protein that contains portions of the extracellular domains of two different VEGF receptors connected to the Fc region
(C-terminus) of a human antibody.
The effectiveness of monoclonal antibodies, particularly those targeting oncology indications, are greatly impacted by the glycosylation, or sugar chain, structure of the antibody's Fc region
Syntonix' SynFusion technology links the Fc region
of an antibody to a drug in a novel manner, resulting in long-acting therapeutic proteins or peptides that can be dosed less frequently.
Syntonix' SynFusion drugs link the Fc region
of an antibody to a drug in a novel manner, providing longer-acting therapeutic proteins or peptides that are injected less frequently.
Acting Director, Division of Monoclonal Antibodies CDER - FDA Role of the Fc Region
in Antibody Function Sherie L.
Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of Physiocrine-based therapeutics to address severe rare diseases, today announced that it has selected an Investigational New Drug (IND) Candidate based on an immuno-modulatory and fibro-modulating Physiocrine domain fused to an Fc region
of a human antibody, iMod.
F-star is the only biotechnology company able to create bispecific antibodies, where the second binding site is in the constant Fc region
of an antibody, offering unprecedented ease in the discovery, development, and manufacturing of bispecific antibody products.
NHance achieves this through 2 specific mutations in the antibody Fc region
(at His433 and Asn434), resulting in an improved affinity of antibody binding to the neonatal Fc receptor at acidic pH.
Rheumatoid factor is an autoantibody targeting the Fc region
of IgG antibodies.
A commercially available recombinant chimeric extracellular sP conjugated with the Fc region
(rhP/Fc) exhibited better performance in terms of stability and affinity toward [CD34.