Fibroblast

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fibroblast

[′fī·brə‚blast]
(histology)
A stellate connective tissue cell found in fibrous tissue. Also known as a fibrocyte.

Fibroblast

 

the basic cellular unit of connective tissue in man and other vertebrates. Fibroblasts produce fibers and the ground substance of connective tissue. They are converted to fibrocytes as a result of differentiation.

References in periodicals archive ?
In this study, we prepared differentiating cells derived from hES cell (d-hES) for use as a feeder cells of embryo co-culture.
The company adds a defined PICM-19H culture system (one free of feeder cells and undefined cell culture medium constituents) may also be important for potential US Food and Drug Administration (FDA) approval of HepaLife's artificial liver device currently under development.
hiPSCs are usually maintained on inactivated Mouse Embryonic Fibroblasts (MEFs) as a feeder, but applying non-human feeder cells can produce biological contaminants such as exogenous antigens, viruses and pathogens.
We do not know if feeder cells were used, and whether they are of human or animal origin.
In addition, to provide physical support for stem cell attachment, feeder cells also affect stem cells by producing various undefined factors through their interactions with stem cells (8).
By studying the differences in genes expressed in cultured mouse iPS cells between cases in which feeder cells are used and those with large amounts of the LIF protein given without feeder cells, they found the CCL2 is also associated with maintaining the pluripotency of iPS cells.
The use of feeder cells in cell culture was first reported by Puck et al.
These feeder cells offer embryonic stem cells a suitable attachment surface and also release largely uncharacterized nutrients into the culture medium that support stem cell growth in the undifferentiated state.
Stem Cells published Geron studies which demonstrated that human embryonic stem cells (hESCs) can be propagated in culture using defined growth factors without the need for feeder cells or media conditioned by feeder cells.
Critics say the lines are aging and may be contaminated with mouse feeder cells.