Ferritin


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ferritin

[′fer·ət·ən]
(biochemistry)
An iron-protein complex occurring in tissues, probably as a storage form of iron.

Ferritin

 

a complex protein (metalloprotein) in which iron is stored in humans and animals. Ferritin is present in the liver, spleen, and bone marrow and in the mucous membrane of the intestines. It was discovered in 1934 by the Czechoslovak scientist Laufberger, who detected the protein in the liver of animals.

Ferritin is the most iron-rich compound in organisms, with approximately one atom of trivalent iron for each amino acid residue of protein. In contrast to hemoproteins, the iron in ferritin is not part of the heme, occurring instead in a complex with the inorganic polymeric compound (FeO·OH)18(FeO·OPO3H2), which is firmly bound to the protein. The molecular weight of ferritin is 747,000; with detachment of the iron, apoferritin is formed, which has a molecular weight of 465,000.

Ferritin exhibits antigenic properties. The ferritin in the mucous membrane of the intestines regulates the absorption of iron and the entrance of iron into the blood. The release of Fe occurs through the action of a reducing agent, in this case ascorbic acid (vitamin C). The iron entering the blood is carried by transferrin to the liver and other organs, where any excess combines with apoferritin. The Fe entering into the composition of ferritin is necessary for the synthesis of hemoglobin, cytochromes, and other iron-containing compounds. An increased need for iron in the body causes a rapid decomposition of ferritin in bone marrow, the liver, and the spleen.

N. N. CHERNOV

References in periodicals archive ?
Ferritin is an acute phase reactant and levels may be falsely elevated due to chronic or acute inflammation, liver disease, renal failure, metabolic syndrome, or malignancy.
Currently, National Health Laboratory Service (NHLS) reports give a normal range of ferritin of 13-150 [micro]g/L for adult women and 30-400 [micro]g/L for adult men.
75 g/dL which was found to be statistically significant but compared to this, increase in serum ferritin was 6.
Also correlation of these hormones with body mass index (BMI), Ferritin and Hemoglobin (Hb) and Kisspeptin levels were further evaluated in beta thalassemic patients undergoing regular blood transfusion with chelation therapy.
Conclusion: The ratio of soluble transferrin receptor to ferritin was lower in higher stages of chronic kidney disease.
Gerec: ve Yontemler: Adnan Menderes Universitesi Tip Fakultesi, Cocuk Hematoloji Anabilim Dali ve Aydin Ataturk Devlet Hastanesi'nde 1 Eylul 2006 ve 30 Eylul 2007 tarihleri arasinda izlenen ve enfeksiyon, enflamasyon, hepatit ve karacigeryetmezligi olmayan 34 TM, 10 Ti'li hastada ve 40 saglikli kontrol grubunda serum prohepsidin ve serum ferritin duzeyine bakildi.
Only 4% children had low ferritin level while 60% had low folic acid and 45% had decreased VitB12.
Control values of serum ferritin and transferrin were obtained from non-pregnant, non-anemic, healthy females of the same age group.
Serum Ferritin levels were obtained from the patients' records and the most recent values were recorded for analyses.
Their serum ferritin and BNP levels were sorted through chemilluminescence based assays employing 8K28 ARCHITECT BNP and 7K59 ARCHITECT ferritin kit on ARCHETECT System(r).
When glycosylated ferritin concentrations are combined with hyperferritinemia, the sensitivity decreases to 43% and specificity increases to 93%.
De-identified ferritin and Hbmass data from 178 athletes engaged in altitude training were extracted from the Australian Institute of Sport (AIS) database.