Ferritin


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ferritin

[′fer·ət·ən]
(biochemistry)
An iron-protein complex occurring in tissues, probably as a storage form of iron.

Ferritin

 

a complex protein (metalloprotein) in which iron is stored in humans and animals. Ferritin is present in the liver, spleen, and bone marrow and in the mucous membrane of the intestines. It was discovered in 1934 by the Czechoslovak scientist Laufberger, who detected the protein in the liver of animals.

Ferritin is the most iron-rich compound in organisms, with approximately one atom of trivalent iron for each amino acid residue of protein. In contrast to hemoproteins, the iron in ferritin is not part of the heme, occurring instead in a complex with the inorganic polymeric compound (FeO·OH)18(FeO·OPO3H2), which is firmly bound to the protein. The molecular weight of ferritin is 747,000; with detachment of the iron, apoferritin is formed, which has a molecular weight of 465,000.

Ferritin exhibits antigenic properties. The ferritin in the mucous membrane of the intestines regulates the absorption of iron and the entrance of iron into the blood. The release of Fe occurs through the action of a reducing agent, in this case ascorbic acid (vitamin C). The iron entering the blood is carried by transferrin to the liver and other organs, where any excess combines with apoferritin. The Fe entering into the composition of ferritin is necessary for the synthesis of hemoglobin, cytochromes, and other iron-containing compounds. An increased need for iron in the body causes a rapid decomposition of ferritin in bone marrow, the liver, and the spleen.

N. N. CHERNOV

References in periodicals archive ?
also supported these findings.7 Many studies into this subject, however, have raised the question of whether serum ferritin levels and other inflammatory markers can serve as a marker in the early diagnosis of type 2 DM, although studies into the issue are lacking.
Analysis of variance (ANOVA) and Spearman correlation were used for comparison of means of more than two groups and correlation of HbA2 levels with Hb and Serum ferritin respectively.
Percent TS >45% or serum ferritin >1000 ng/mL were included for mutation analysis of C282Y for HFE genotype.
This cross-sectional study was done on 50 children of beta thalassemia major, who received regular blood transfusion therapy for at least two years and were selected with a ferritin level is greater than 1000 [micro]gm/dl.
Routine blood samples for red cell indices (MCV, MCH, MCHC and RCDW), serum haemoglobin, creatinine, C-reactive protein (CRP), iron, transferrin, TSAT and ferritin were analysed.
At the outset, the mean haemoglobin was 107 g/L, ferritin 101.3 ug/L and Tsat 12.4%.
Using this approach, we aimed to investigate the causal effect of an increase in ferritin concentration as a marker of increased iron concentration on the concentrations of C-reactive protein (CRP)9 and complement component 3 (C3) using genetic instruments.
Five milliliter of the blood of the selected children was drawn for full blood count and ferritin levels.
The normal serum ferritin (<100 ng/mL) and normal CRP levels accompanied with normal FPN among the diabetic patients without IDA are strongly against the association of IDA with chronic inflammatory state.
Small quantities of ferritin are also present in the serum, due to secretion from macrophages, or following cell death and lysis [31].
to analyze the type of thyroid dysfunction and its association with duration and amount of blood transfusions, serum ferritin level, and adequacy of chelation.
Ferritin levels were determined by the enzyme immune assay (ELISA kit, Pishtaz Teb Ltd, Tehran, Iran) according to the manufacturer's protocol.