Maternal vascular malperfusion with marked fibrinoid necrosis
of spiral arterioles and occasional lack of remodeling (hematoxylin-eosin, original magnification X10).
5) Absence of significant leukocytoclasis, neutrophil/eosinophil infiltrate and fibrinoid necrosis
argues against the alternative etiology such as polyarteritis nodosa and anti-neutrophil cytoplasmic antibodies vasculitis in our patient.
4) There is also evidence that tumefactive fibroinflammatory lesions may be predisposed by radiation therapy, (1) as evidenced by the presence of pseudoepitheliomatous hyperplasia, chronic inflammation, extensive fibrin deposition, and fibrinoid necrosis
of blood vessels in this case.
The results revealed that in the irradiated group (Group II), the myocardial muscles were necrotic with leucocytes infiltration, fibrinoid necrosis
in coronary vessel, edema and hyalinization of myocardial muscles were remarked which is in agreement with the previous results observed by Baker et al.
2010 has documented that in GDM treated with diet only, placentae showed fibrosis and ischemic changes, more syncytial knots, mild edema and fibrinoid necrosis
, which is similar to our results.
Caption: Figure 3: Histopathological section ((a) prostate; (b) lung) showed fibrinoid necrosis
, and the inflammatory infiltrate was predominantly composed of neutrophils, lymphocytes, and histiocytes (hematoxylin-eosin stain, original magnifications of (a) and (b) are 100x).
Comparison of the morphological picture of placentas of women with genital infection with the data of ultrasonic placento- and fetometry and microbiological studies in case of amniotic waters infection showed that there was more pronounced degree of circulation violation with swelling and spasm of the villi, fibrinoid necrosis
, leukocyte infiltration in almost all cases of intraamniotic infection.
Medium to small sized vessels showed fibrinoid necrosis
with plump endothelial cells and neutrophils.
Pathological examination showed mitral and aortic valvular fibrosis with hyaline degeneration and calcification, multifocal fibrinoid necrosis
, bacterial colonies, tissue infiltration of many neutrophils, lymphocytes, and plasma cells as well as granulation tissue formation [Figure 2]c and d.
Multiple vessels demonstrated fibrinoid necrosis
of the vascular wall and microthrombi due to extensive neutrophilic vasculitis (Fig.
The evidence of destructive processes in the vessel wall increased significantly and was accompanied by fibrinoid necrosis
, accumulation of the large quantity of fibrin in the intima and media, swelling and destruction of collagenous fibers, exactly these conditions can be connected with the increase of cell's reaction.
Histological analysis of the small bowel segment revealed the presence of a small vessel vasculitis with typical fibrinoid necrosis
suggestive of HSP (figure 3).