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Related to Fibroblast: chondroblast, Fibrocyte, myofibroblast


A stellate connective tissue cell found in fibrous tissue. Also known as a fibrocyte.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the basic cellular unit of connective tissue in man and other vertebrates. Fibroblasts produce fibers and the ground substance of connective tissue. They are converted to fibrocytes as a result of differentiation.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Fibroblasts control local and distant angiogenesis mediated by bone marrow stem cells; however, they are transformed into invasive types and myofibroblasts (De Wever & Mareel 2003; Orimo et al., 2005) within the stroma of invasive cancers of the breast, colon, ovaries, pancreas and prostate (Kalluri & Zeisberg, 2006).
Pressure elevation slows the fibroblast response to wound healing.
TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.
Type I and III collagens expression in ADSCs-induced fibroblasts under the optimized concentration of combined basic fibroblast growth factor and epidermal growth factor treatment
According to the company: "SpinalCyte's Phase 1/Phase 2 clinical trial for injected human dermal fibroblasts in the treatment of DDD demonstrated preliminary six-month data whereby 83 percent of patients had an increase or no change in disc height."
KEYWORDS: Hypertrophic Scar, Fibroblast Cell, Lipopolysaccharide, Mitogen-Activated Protein Kinase.
Similarly, when miRNA-133 was used in conjunction with GMT, Mespl, and Myocd or GHT, Myocd, and miRNA-1, the reprogramming efficiency was increased in both human and mouse fibroblasts by repressing Snai1 and silencing fibroblast gene signatures [35, 37].
The atrial fibroblast model was based on the active 1 model described by Maleckar et al.
Myofibroblasts isolated from the mouse lungs were seeded (0.1 x [10.sup.6]) on 22 x 22 mm glass coverslips in fibroblast culture medium.
TNF-[alpha] (Miltenyi Biotec, cat nr 130-094014) (10 ng/ml) was used as a positive control in fibroblast experiments.
Hypertrophic scars These occur when the skin makes too many fibroblasts as the acne spot heals, causing a raised scar.
On day 5, in group A 70% animals showed only few fibroblasts in the wound field, while none of the animals showed prominent fibroblasts which indicates that inflammation is in progression phase.