fibrosis

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Related to Fibrogenesis: fibrosis, fibrose

fibrosis

the formation of an abnormal amount of fibrous tissue in an organ or part as the result of inflammation, irritation, or healing

fibrosis

[fī′brō·səs]
(medicine)
Growth of fibrous connective tissue in an organ or part in excess of that naturally present.
References in periodicals archive ?
The immunologic and molecular biomarkers have been described in the context of ARDS pathogenesis and their major biologic activity on inflammation, endothelial and epithelial cell damage, fibrogenesis, and abnormal lung mechanics.
This study has attempted to elucidate the role of ACKR1 polymorphism in liver fibrosis progression of HCV infection, but our results demonstrated that ACKR1 polymorphism is not directly associated with the fibrogenesis in HCV positive patients by using non-invasive serum liver related markers.
Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloride-treated rats: effect of zinc administration.
However, if drinking continues, chronic inflammation and sustained fibrogenesis progress, resulting in the substitution of liver parenchyma by scar tissue that severely compromises the liver's vascular architecture.
These parameters reflect both the presence of endothelial dysfunction and activation of fibrogenesis mechanisms that are key steps in the process of remodelling microvascular system of kidney in hypertensive nephropathy [5].
Switching the committed stem cells from myogenesis to fibrogenesis or adipogenesis are competitive process and reduce muscle fiber number while increasing fat and connective tissue in muscle (Yan et al.
In addition, TNF-[alpha] is known to stimulate expression of TGF-[beta] in fibroblasts, a key factor for fibrogenesis, through activation of the extracellular signal-regulated kinase pathway and the over-production of pro-inflammatory cytokines through the NF-[kappa]B pathway (Sullivan et al.
Unnecessary augmentation of immunosuppression can accelerate fibrogenesis in chronic HCV or trigger cholestatic hepatitis27, however, untreated acute cellular rejection can progress to chronic rejection.
Some fibrils feature free ends, while others are bifurcated, the latter being attributed to collagen undergoing fibrogenesis.
And a recent study has demonstrated that KLF-4 is downregulated during EMT in renal fibrosis and functions as a suppressor of renal fibrogenesis [14].
Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure.