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A sarcoma composed of spindle cells that produce collagenous fibrils.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



an immature malignant tumor of connective tissue; a malignant variant of fibroma, fibromyoma (leiomyoma), or fibroadenoma that can occur in any part of the body. It is characterized by invasive and destructive growth but sometimes has distinct contours. In cross section it looks like fish flesh. A fibrosarcoma has a marked capacity to metastasize, chiefly through blood vessels. It can often be distinguished from a fibroma only by histological examination and is treated surgically.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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A vaccine of recombinant canarypox virus expressing feline interleukin-2 (IL-2) is approved for use in Europe as adjunctive immunotherapy after surgery for some feline cancers, including feline injection-site sarcomas, or fibrosarcomas. (IL-2 is an important T cell stimulatory cytokine approved as an exogenous antitumor agent.)
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TRK fusion cancer occurs in various adult and pediatric solid tumors with varying frequency, including lung, thyroid, gastrointestinal cancers (colon, cholangiocarcinoma, pancreatic and appendiceal), sarcoma, CNS cancers (glioma and glioblastoma), salivary gland cancers (mammary analogue secretory carcinoma) and pediatric cancers (infantile fibrosarcoma and soft tissue sarcoma).
Ameloblastic fibrosarcoma of the mandible: treatment, long-term follow-up, and subsequent reconstruction of a case.
For differential diagnosis, we used the special Masson's trichrome staining, which aided visualization of muscle fibers within the neoplasia and ruled out the possibility of fibrosarcoma. However, this staining did not permit differentiation between leiomyosarcoma and rhabdomyosarcoma, necessitating immunohistochemical evaluation, which revealed neoplastic cells with intense and diffuse cytoplasmic immunoreactivity for vimentin and alpha smooth muscle actin.
The final diagnosis of the patient was thyroid fibrosarcoma with pulmonary and subcutaneous adipose metastasis accompanied with solitary PSH in the left lung.
Differential diagnosis included gastrointestinal smooth muscle tumor, leiomyosarcoma, fibrosarcoma, and malignant peripheral nerve sheath tumor.
Dominic Paul, 24, was in his second year of his degree at the University of South Wales in 2015 when he was diagnosed with fibrosarcoma - which affected soft tissue at the top of his back.
(4) Muller et al reported that since 1960, 44% cases of ameloblastic fibrosarcoma (19/43) had arisen from ameloblastic fibroma.
Congenital infantile fibrosarcoma (CIF) represents a malignant mesenchymal tumor accounting for 10-20% of softtissue tumors diagnosed in the early years of life [1].