fetal hemoglobin

(redirected from Foetal haemoglobin)
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Related to Foetal haemoglobin: Hb F, Haemoglobin F

fetal hemoglobin

[′fēd·əl ′hē·mə‚glō·bən]
(biochemistry)
A normal embryonic hemoglobin having alpha chains identical to those of normal adult human hemoglobin, and gamma chains similar to adult beta chains.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Foetal haemoglobin, a form of haemoglobin with a greater affinity for oxygen compared to adult haemoglobin.
Gregorj et al., "Foetal haemoglobin, erythrocytes containing foetal haemoglobin, and hematological features in Congolese patients with sickle cell anaemia," Anemia, vol.
Changes in maternal haemoglobin concentration and haematocrit value at the end of gestation, placental morphology and foetal haemoglobin concentration and haemotocrit value at birth were used as indicators for the degree of maternal, placental and fetal hypoxia respectively.
The only definitive and curative treatment available is bone marrow transplant from an HLA-identical donor.1 The observation that hydroxyurea (HU) can cause a rise in foetal haemoglobin (HbF) in sickle cell disease led many investigators around the globe to exploit its potential in other haemoglobinopthies.2 The precise mechanism of action is not yet clear, but it appears that HU increases nitric oxide levels, causing soluble guanylyl cyclase activation with a resultant rise in cyclic GMP, and the activation of gamma-globin synthesis necessary for HbF.3 These newly-formed gamma-globin chains competitively bind with alpha-globin chains.
Carriers of [delta][beta]-thalassaemia also have reduced or near normal [HbA.sub.2] levels with increased foetal haemoglobin levels.
This drug helps decrease the number and severity of attacks by boosting production of foetal haemoglobin.