(redirected from Folliculin)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.


C18H22O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; functions the same as estradiol.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



C18H22O2, a female sex hormone of the estrogen group. Estrone occurs as colorless crystals with a melting point of 259°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +170°.

Estrone was first isolated in 1929 from the urine of pregnant women by A. Butenandt and the American biochemist E. Doisy. Specific sources rich in the hormone are the urine and testes of stallions. The hormone is readily converted both metabolically and chemically into estradiol, a hormone that has higher estrogenic activity. Estrone is found not only in animals and humans, but also in certain fruits, such as the coconut, apple, and pomegranate. Because its structure is so simple, many methods for the complete chemical synthesis of estrone have been developed. The most economical of these was suggested by the Soviet scientist I. V. Torgov in 1962.

Estrone has important physiological functions (see).

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Dydensborg et al., "Renal tumour suppressor function of the BirteHoggeDubee syndrome gene product folliculin," Journal of Medical Genetics, vol.
Novel mutations in the folliculin gene associated with spontaneous pneumothorax.
Abbreviations FLCN: Folliculin RCC: Renal cell carcinoma BHD: Birt-Hogg-Dube syndrome CT: Computed tomography RFA: Radio frequency ablation mTOR: Mammalian target of rapamycin AMPK: AMP-activated protein kinase MRI: Magnetic resonance imaging US: Ultrasound PSP: Primary spontaneous pneumothorax HLRCC: Hereditary leiomyomatosis and renal cell carcinoma VHL: Von Hippel-Lindau syndrome HPRC: Hereditary papillary renal carcinoma.
(85) Genetic predisposition to the development of ChRCC, particularly so-called hybrid oncocytic/chromophobe tumors that show overlapping features of oncocytoma and ChRCC, is seen in patients with Birt-Hogg-Dube syndrome, which is associated with germline folliculin (FLCN) mutations; these patients often develop multiple, bilateral, oncocytic renal neoplasms, including ChRCC, hybrid oncocytic/chromophobe tumors, and oncocytoma, and may also have characteristic skin (ie, fibrofolliculomas, trichodiscomas) and lung (ie, subpleural cystic blebs) findings.

Full browser ?