Formamides have played a significant role in organic synthesis.
In order to overcome the mentioned drawbacks, we need to develop a better protocol for synthesis of formamides in terms of operational simplicity and economical viability.
More examinations also resulted that in the case of benzylic and aromatic secondary amines such as benzylamine and N-methylaniline, the protocol was also efficient and produced the corresponding formamides in 88-90 % yields (entries 18 and 19).
Klein, Preparation of Nitriles from Formamides, U.S.
Faraj, Synthesis of Isocyanate Precursors from Primary Formamides, U.S.
Vaziri, Zr-MCM-41 Nanoreactors: a Highly Efficient, Reusable and Novel Catalyst for the Synthesis of N-heteroaryl Formamides Under Solvent-Free Conditions, J.
When the reaction was completed, the mixture was passed through a short column of silica gel (200-400 mesh) and the eluted solvent was then evaporated under reduced pressure to afford the pure N-phenyl formamide in 95% yield (0.115 g, Table-2, entry 1).