founder effect

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founder effect

[′fau̇n·dər i‚fekt]
(genetics)
The overrepresentation of a specific allele at one or more loci in a new population that arises from a small number of individuals whose small gene pool may be unrepresentative of the parental population initially or as a result of the ensuing genetic drift.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Clinical and molecular manifestation of fifteen 17OHD patients: a novel mutation and a founder effect. Endocrine 2016;53:784-790.
Of the six people that had the mutation, five instances could be traced to founder effects, and one case could be traced to a marriage between close relatives.
Invasive species are predicted to suffer from reductions in genetic diversity when only a few individuals from the source population colonize new habitats, thus undergoing the founder effect and reducing adaptive potential (Mayr, 1963; Allendorf & Luikart, 2007).
[13.] Rivera D, Mejia-Lopez H, Pompa-Mera EN, et al Two different PABPN1 expanded alleles in a Mexican population with oculopharyngeal muscular dystrophy arising from independent founder effects. Br J Ophthalmol 2008;92(7):998-1002.
The high gene frequency is due to founder effects and high incidence of consangious marriages in the above populations.
Model 3, the constrained founder effect model, also significantly increments the control model (Nagelkerke [R.sup.2] = .131, [DELTA][R.sup.2] = .040, F = 6.076, p < .05).
In some populations with founder effects, BRCA1/2 mutations are far more frequent and account for a greater proportion of familial aggregation and breast cancer overall.
This could further compound founder effects with a resulting higher risk of suboptimal trait sizes.
Clinical patterns of human Y chromosomal diversity in continental Italy and Greece are dominated by drift and founder effects. Molecular Phyogenetics and Evolution 28: 387-95.
The results underscore the importance of human transport as a dispersal mechanism and the importance of genetic drift and founder effects in determining population genetic structure.