fragile site

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fragile site

[′fraj·əl ¦sīt]
(genetics)
The chromosomal position of a deoxyribonucleic acid sequence predisposed to spontaneous or induced breakage; sometimes contains short repetitive sequences.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The exhibition carries a significant message about the importance of preserving and protecting these precious but fragile sites -- one which resonates strongly in the week when one of the world's most-famous heritage sites, Paris' Notre-Dame Cathedral, went up in flames.
Based onSeralini [16]and Dryginet al, [17], the GM food may lead to chromosome fragile sites in general and may lead to cancer development.
FRA3B and other common fragile sites: the weakest links.
Human micro-RNA genes are frequently located at fragile sites and genomic regions involved in cancers.
Chromosomal fragile sites expressed through an increased frequency in gaps and breaks are identified, as well as a presence of conservation of fragile sites throughout evolution [13, 14].
FRAXA is a mental retardation disorder associated with one of the seven folate-sensitive fragile sites that have been identified within human chromosomes.
A growing body of evidence suggests that specific fragile sites in human chromosomes play roles in tumorigenesis.
Key words: dog, mammary tumors, cytogenetic, fragile sites.
Abstract.- A Study to compare the extent of geno-environmental interaction expressed as fragile sites was carried out in British Suffolk and Pakistani Lohi breeds of sheep (Ovis aries).
Possible correlations between chromosome breakpoints other than 9 and 22 in these Ph variant tranlocations, and recent updates for the map locations of consistent cancer breakpoints, fragile sites, and oncogenes are discussed.
Frequency, association and genetic implications of chromosomal fragile sites in mental retardation.