frameshift mutation

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frameshift mutation

[¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
References in periodicals archive ?
c.103 locus in exon 4 is also found altered in three human studies, two studies were conducted by (Mitsudomi et al., 1992)on NSCLC, in which insertion were observed and appeared as frame shift mutations, another study by (Lee et al., 2010) showed the same results, while one study conducted by (Temam et al., 2003) on human head and neck SCC which showed deletion at the same locus.
During the training stage, the training data are divided into frames with 25 ms frame length and 10 ms frame shift. The 12-dimensional MFCC feature is extracted for each frame and, along with short time energy, forms a 13-dimensional vector.
HNH nuclease is reported to be involved in cleavage of complementary strand while Ruvc cleaves the non-complementary strand resulting in the blunt end formation which after re-union gives frame shift mutations or indels [9]
Sequencing of the relevent WISP3 gene revealed a novel homozygous frame shift mutation in exon 5 (c.935_936insT;p.C314Lfs*7).
In DMD patient genomes, the deletion of the dark blue exon leads to a frame shift, disrupting the ORF and causing a premature stop codon.
Moreover, the walk shifts in direction from a TP intensive region to a neighboring one and the angle of the "corner" indicate the frame shift A between the two regions, following a "corner rule" [24].
In the blink of the eye, figures in one frame shift in the next or are replaced by mirror figures.
Among [beta]-globin gene mutations, HBB: c.25_26delAA (Cod 8 [-AA]), which results in frame shift and stop codon at the 21st amino acid, is a rare mutation with an incidence of 2.1 % among all 13-globin gene mutations in Antalya Province (5).
Predictably, this message results in a frame shift in the translated protein, a substitution of serine 348 to lysine, and the insertion of 92 new amino acids before a premature stop is encountered at residue 440 (Ser348LysfsX93).
NSP 3b (22 aa) was 49 aa shorter than expected because of a 38-nucleotide deletion and a frame shift mutation in the downstream sequence that introduced an early stop codon.
The discussion is on the change from "war on terrorism" to "global struggle against violent extremism." Frame shift? Metaphor shift?
The combined homozygosity of these two genetic alterations in the UGT1A1 promoter can reduce the transcriptional activity of this gene to <30% of normal.[sup][3] In addition, higher bilirubin levels were found in patients with the p.I448V mutation compared to those with no mutations, suggesting that this mutation may severely disrupt transporter activity.[sup][4] The combination of this mutation with the frame shift mutation in a compound heterozygote may play a role in the slow clearance of conjugated bilirubin and/or the expression of enzymes involved in the cyclization of hydroxymethylbilane.