frameshift mutation

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Related to Frame shift mutation: point mutation, missense mutation

frameshift mutation

[¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
References in periodicals archive ?
Sequencing of the relevent WISP3 gene revealed a novel homozygous frame shift mutation in exon 5 (c.935_936insT;p.C314Lfs*7).
Recently, a novel heterozygous frame shift mutation (c.510delA) within SLC20A2 exon4 was identified in a Chinese family with IBGC 11.