frameshift mutation

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Related to Frame shift mutation: point mutation, missense mutation

frameshift mutation

[¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
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References in periodicals archive ?
Sequencing of the relevent WISP3 gene revealed a novel homozygous frame shift mutation in exon 5 (c.935_936insT;p.C314Lfs*7).
A NEW MUTATION IN THE WISP3 GENE (c.935_936insT;p. C314Lfs*7) IN A PATIENT WITH PROGRESSIVE PSEUDORHEUMATOID DYSPLASIA
Recently, a novel heterozygous frame shift mutation (c.510delA) within SLC20A2 exon4 was identified in a Chinese family with IBGC 11.
Mutation analysis of 5LC20A2 and 5PP2 as candidate genes for familial idiopathic basal ganglia calcification
Cod 8 (-AA) is a frame shift mutation that creates a stop codon at the 21st codon, leading to 130-thalassemia.
The effect of HBB:c.*+96T>C (3'UTR +1570 T>C) on the mild [beta]-thalassemia intermedia phenotype / HBB:c.*+96T>C (3'UTR +1570 T>C) mutasyonunun ilimli tip beta-talasemi intermedia fenotipi uzerine etkisi

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