frameshift mutation

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frameshift mutation

[¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Additional characterization of SINV-3 has revealed that it produces its capsid proteins from a subgenomic RNA via a frameshifting mechanism (Valles et al.
NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness.
A basis for new approaches to the chemotherapy of AIDS: novel genes in HIV-1 potentially encode selenoproteins expressed by ribosomal frameshifting and termination suppression.
The specific topics include phage and bacterial genetics at Cold Spring Harbor Laboratory, the genetics of the heme pathway and its regulation, complementary studies in the histidine operon and on frameshifting, the adaptable plan of attack deployed by pathogenic bacteria, mutation and selection in beehive and cow country, and the impact of horizontal genetic transfer on the evolution of bacterial genomes.