Friedlander synthesis

Friedlander synthesis

[′frēd‚lan·dər ‚sin·thə·səs]
(organic chemistry)
A synthesis of quinolines; the method is usually catalyzed by bases and consists of condensation of an aromatic o-amino-carbonyl derivative with a compound containing a methylene group in the alpha position to the carbonyl.
References in periodicals archive ?
The optimization of Friedlander synthesis of quinolines (Scheme 26) was carried out on various of 2-aminoaryl ketones, 2.19.16, active methylene compounds, 2.19.17, and simple cyclic ketones, 2.19.18, under different catalysts (Ti[O.sub.2], Si[O.sub.2], [Al.sub.2][O.sub.3], ZnO, MgO, CuO bulk and nano-CuO) in solvent-free condition at 60[degrees]C, and nano-CuO was found superior to all the other catalysts [110].