fumarase

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fumarase

[′fyü·mə‚rās]
(biochemistry)
An enzyme that catalyzes the hydration of fumaric acid to malic acid, and the reverse dehydration.
References in periodicals archive ?
42) HLRCC is characterized by germline mutations in the fumarate hydratase (FH) gene on chromosome 1q42, which encodes a Krebs cycle enzyme that catalyzes the conversion of malate to fumarate.
Evidence for a founder effect of the germline fumarate hydratase gene mutation R58P causing hereditary leiomyomatosis and renal cell cancer (HLRCC).
The hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) are caused by heterozygous germline mutations of the fumarate hydratase (FH) gene on chromosome 1q34.
The teams pooled their efforts and report in an upcoming issue of Nature Genetics the discovery of mutations of the gene that encodes an enzyme called fumarate hydratase.