G protein

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Related to G-protein: Adenylyl cyclase

G protein

[′jē ‚prō‚tēn]
(cell and molecular biology)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Specific G-protein mutations have been identified in two case reports of patients with cholestasis and MAS (4,5).
GO analysis showed that G-protein coupled receptor protein signaling pathway, intrinsic to membrane, cell junction and ion transport were significantly enriched, and KEGG analysis indicated that neuroactive ligand-receptor interaction was the only significantly enriched pathway (Table IV).
Confo Therapeutics has entered into a research collaboration and license agreement with Roche for the discovery, development and commercialization of novel, small molecule agonists of an undisclosed G-protein coupled receptor (GPCR) for the treatment of neurological and developmental disorders.
The clinical trial findings were presented at the annual meeting of the Endocrine Society by Graeme Fraser, PhD, chief scientific officer for Ogeda, the company that is developing fezolinetant, one of a class of drugs that targets G-protein coupled receptors.
Ogeda is a clinical-stage firm that discovers and develops small molecule drugs targeting G-protein coupled receptors.
The [G.sub.q] class is one subfamily of the G protein alpha subunit family and is comprised of four genes: G-protein subunit Galphaq (GNAQ), GNA11, GNA14, and GNA15 (Davignon et al., 1996; Chen et al., 2008).
rosea were listed, including effects on key mediators of stress response, regulation of homeostasis of hypothalamic-pituitary-adrenal axis activity, modulation of the G-protein coupled receptors and associated signalling pathways, upregulation of neuropeptides, and other molecular networks involved in depression.
On the other hand, the expression of TrkB receptor was shown to be regulated by G-protein coupled receptor via cAMP signaling (Aloyz et al., 1999; Samarajeewa et al., 2014).
Global Markets Direct's, 'Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) - Pipeline Review, H1 2016', provides in depth analysis on Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) targeted pipeline therapeutics.
Moreover, many studies have shown that chemokine receptors can interact with multiple G-protein subtypes; the coupling is cell type-specific [32].
Background: G-protein [sz]-polypeptide 3 (GNB3) is a [sz] subunit isoform of G-protein that plays important role in signal transduction of membrane G-protein coupled receptors (GPCRs).