G-protein-linked receptor

G-protein-linked receptor

[¦jē ‚prō‚tēn ‚liŋkt ri′sep·tər]
(cell and molecular biology)
A cell surface receptor that consists of a polypeptide chain threaded across the membrane seven times and that, when activated by the binding of a ligand, in turn activates a cytosolic G-protein molecule, which then initiates a cascade of reactions effecting the intracellular response to the extracellular signal (the ligand).
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References in periodicals archive ?
Nociceptin does not signal through the previously described polycation receptor of Tetrahymena thermophila nor does it signal through a G-protein-linked receptor, as it does in humans.
Matsui, "Allosteric regulation of G-protein-linked receptors," Biochemical Society Transactions, vol.