G-protein-linked receptor

[¦jē ‚prō‚tēn ‚liŋkt ri′sep·tər]

(cell and molecular biology)

A cell surface receptor that consists of a polypeptide chain threaded across the membrane seven times and that, when activated by the binding of a ligand, in turn activates a cytosolic G-protein molecule, which then initiates a cascade of reactions effecting the intracellular response to the extracellular signal (the ligand).

Mentioned in ?

acetylcholine receptor

References in periodicals archive ?

Nociceptin does not signal through the previously described polycation receptor of Tetrahymena thermophila nor does it signal through a G-protein-linked receptor, as it does in humans.

Nociceptin signaling involves a calcium-based depolarization in Tetrahymena thermophila

Matsui, "Allosteric regulation of G-protein-linked receptors," Biochemical Society Transactions, vol.

[A.sub.3] adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action