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There are several different classes of G-proteins, which are defined by their different G[alpha] subunits.
The inhibitory action of hypothalamic dopamine on pituitary prolactin secretion is mediated by the dopamine G-protein--coupled D2 receptors (D2R), which interact with regulatory molecules called G-proteins and specifically a subtype called adenylyl-cyclase--inhibitory Gi/Go (Ben-Jonathan et al.
D2R acts by ligand-dependent signalling through two major systems: the G-proteins, and the Arrestin proteins (Arr-s).
Since its discovery as an intracellular protein with similarities to [sz]-subunits of G-proteins, a whole wealth of potential functions for RACK-1 have been described, including its participation as a scaffold protein, [sup] activator of protein kinase C [sup] and binder and activator of inositol trisphosphate receptors.
G-proteins trigger a great many cellular processes.
3) Examples of drugs that act via G-proteins are opioids, ranitidine (used to decrease acid secretion in the stomach), and beta-agonists such as salbutamol and adrenaline.
Compound 48/80 is a substance that activate mast cell secretory processes by increasing the rate of GTP S binding to G-proteins (Go/Gi mixture) (Mousli et al.
discoideum; methods for measuring spatiotemporal dynamics of chemoattractant concentrations, activation of receptors, heterotrimeric G-proteins, small G-protein Ras signaling, and actin cytoskeleton assembly using different imaging techniques; and the use of computer-based quantitative models for addressing the complexity of a signaling network.
Recent studies have indicated that organophosphorus pesticides (OPs) may disrupt metabolism by altering the expression or function of adenylyl cyclase (AC; the enzyme that catalyzes the formation of cAMP from ATP) or G-protein-coupled receptors and G-proteins involved in the AC signaling cascade.
Statins decrease the products of the mevalonate pathway, including geranylgeranylpyrophosphate, which is required for the activity of small G-proteins (3).
Good old G-proteins weren't the complete story, I realized, since some of these things could signal through various kinase pathways, and then there was all that craziness with beta-arrestins, and on and on.
the production of aldosterone was previously thought to be solely the result of the activation of G-proteins.
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