CA VII activity regulates neuronal pH and maintains bicarbonate gradients in the brain for the management of neuronal channels by GABA receptors (GABARs
For this reason, in insects, other proposed mechanisms of EO action include the inhibition of GABA receptors (GABArs
) and the alteration of the octopaminergic system.
GABA's natural function is to reduce the activity of the neurons to which it binds through GABA receptors (GABARs).
GABARs are promising drug targets for a wide spectrum of psychiatric and neurological disorders.
Repeated alcohol exposure during the third trimester of pregnancy increases expression of GABARs in cerebellar granule neurons and delays motor development in rats.
It was demonstrated that the absence of functional GABARs disturbs glucose homeostasis in mice.
In this work we demonstrate for the first time the presence of functional ionotropic GABA receptors (GABARs) in cellular membranes microtransplanted from the squid stellate ganglion to Xenopus oocytes.
In contrast, 80% of all the oocytes injected with the membranes elicited GABA-activated currents ([I.sub.GABS]) of -48.3 [+ or -] 18.0 nA (range--2.7 to--106.8 nA), clearly indicating that squids express ionotropic GABARs that were successfully transplanted to Xenopus oocytes (Fig.
Physiological properties of GABARs from the squid stellate ganglion
GABARs mediate the majority of inhibitory neurotransmission in the brain.
Interestingly, ubiquitination appears to target mainly GABARs residing in the ER.
Die lyk is uitgetrollie in 'n wit laken; die verkrimpte ou weduweegesiggie wat die coons gasien het niewedjare ennie kinners doedgan specially vi Kytie kos even so was sy my kind gawies en om so te gan; die verkrimpte ou handjies, dis so gabars
sien meneer vannie ouderdom hehehe ennie char specially die char, kos ek het vir 'n rukketjie die blomme oek gahad en oekie pars, wat, toe die polisie daarmee klaar was, Klein Kytie se lyk ingeneem het, die skandes reg gesien het en toe ma gatry het ommit yt te le virrie kis ..." ("Klein Kytie" 90).