Galactosamine


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galactosamine

[gə‚lak′tō·sə‚mēn]
(biochemistry)
C6H14O5N A crystalline amino acid derivative of galactose; found in bacterial cell walls.

Galactosamine

 

(also chondrosamine, 2-amino-2-deoxygalactose), an amino sugar; first isolated from cartilaginous tissue. A strong base, readily soluble in water, and optically active.

An important derivative of glactosamine is N-acetyl-galactosamine, which is present as a repeating unit in chondroitin; N-acetylgalactosamine sulfate is present in chondroitin sulfates and keratosulfate. Along with glucosamine, galactosamine is a structural element in the polysaccharide of group-specific mucoids in humans and animals and also as part of the specific polysaccharide of pneumococci.

References in periodicals archive ?
Schwartz et al., "Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and D-chiroinositol," Biochemical and Biophysical Research Communications, vol.
Acute hepatic injury was induced by the highly specific hepatotoxin galactosamine (Sigma-Aldrich, Spruce St., St Louis, USA) (2.5 g/kgi.p.) [8].
We also found that catechin-rich green tea prevented liver fibrosis after hepatic injury induced by galactosamine through the down-regulation of the gene expression of collagens.
Medicinal properties include anti-inflammatory, hepatoprotective activities against galactosamine, paracetamol intoxication, cancer therapy and anti HIV activity (Puri 1993).
Free radical scavenging and hepatoprotective activity of Jigrine against galactosamine induced hepatopathy in rats.
Isolation and characterization of isolectins with galactose/N-acetyl galactosamine specificity from hemolymph of the giant silkworm Hyalophora cecropia.
These enzymes have been shown to hydrolyse heparan sulphate, which consists of N-acetylated or N sulphated glucosamine or galactosamine linked to glucoronic or iduronic acid.
Acid monosaccharides (galacturonic, glucoronic) and amino sugars (galactosamine, glucosamine) were found in smaller proportions.
D-chiro-Inositol is a component of galactosamine D-chiro-inositol, a putative insulin mediator (Larner et al., 1988; Romero and Larner, 1993), believed to be deficient in subjects with NIDDM (Asplin et al., 1993) because of abnormal D-chiro-inositol metabolism (Kennington et al., 1990; Ortmeyer et al., 1993).
By the same strategy, the SVM was able to recognize animals that had been exposed to the hepatotoxicant galactosamine but failed to respond with the typical necrosis and inflammation of the liver.
The test screens a mucus sample for a specific galactosamine that is secreted in excessive amounts by tumors.
Andrographis was also found to be superior to silymarin in protecting the liver against paracetamol toxicity [16] and against paracetamol and galactosamine. [7]