Gamma-Aminobutyric Acid

(redirected from Gamma Hydroxy Butyrate)
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Gamma-Aminobutyric Acid

 

NH2CH2CH2CH2COOH, an acid formed by the decarboxylation of glutaminic acid under the action of the enzyme decarboxylase. In the body, metabolism of gamma-aminobutyric acid gives succinic acid, which participates in the tricarboxylic acid cycle. Free gamma-aminobutyric acid is found in many plants. In higher mammals gamma-aminobutyric acid is only found in the brain, where its concentration reaches 100 mg percent. Gamma-aminobutyric acid is assumed to exert a retarding action on nerve activity, which is apparently associated with its effect on the permeability of biological membranes.

References in periodicals archive ?
Gamma hydroxy butyrate, originally developed as a surgical anesthetic and usually sold as a colorless and odorless liquid, provides users with a relaxed, uninhibited feeling.
Gamma hydroxy butyrate (GHB) is a central nervous system depressant approved as an anaesthetic in some countries; however, with the exception of investigational research, it is not approved for any use in the United States.
Abby Reading is believed to be the first person to die from taking gamma hydroxy butyrate, dubbed GBH because of its dangerous side effects.
But liquid gamma hydroxy butyrate, used by doctors as an anaesthetic, is now the favoured weapon of date rapists.
In August the complaints took on a new urgency when one man died of an overdose of the drug gamma hydroxy butyrate (GHB) the evening before the party and 21 revelers were arrested at the festivities for drug possession.
On August 7, 1990, the San Francisco Bay Area Regional Poison Control Center notified the regional office of the Food and Drug Administration (FDA) and the California Department of Health Services of acute poisonings attributed to ingestion of gamma hydroxy butyrate (GHB), which recently has been illicity marketed nationwide.